533717 Sigma-AldrichGLS1 Inhibitor III, CB-839 - CAS 1439399-58-2 - Calbiochem
Cell-permeable, orally available, potent, selective & non-competitive GLS1 inhibitor. Reduces glutamine consumption & glutamate secretion, and induces apoptosis.
More>> Cell-permeable, orally available, potent, selective & non-competitive GLS1 inhibitor. Reduces glutamine consumption & glutamate secretion, and induces apoptosis. Less<<Synonyms: N-(6-(4-(5-((2-Pyridin-2-ylacetyl)amino)-1,3,4-thiadiazol-2-yl)butyl)pyridazin-3-yl)-2-(3-(trifluoromethoxy)phenyl)acetamide, KGA Inhibitor III, 2-(Pyridin-2-yl)-N-(5-(4-(6-(2-(3-(trifluoromethoxy)phenyl)acetamido)pyridazin-3-yl)butyl)-1,3,4-thiadiazol-2-yl)acetamide, GAC Inhibitor III, Kidney-Type Glutaminase Inhibitor III
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Overview
Key Spec Table
CAS # | Empirical Formula |
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1439399-58-2 | C₂₆H₂₄F₃N₇O₃S |
Pricing & Availability
Catalogue Number | Availability | Packaging | Qty/Pack | Price | Quantity | |
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5.33717.0001 |
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Glass bottle | 10 mg |
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References | |
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References | Gross, M.I., et al. 2014. Mol. Cancer Ther. 13, 890. |
Product Information | |
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CAS number | 1439399-58-2 |
Form | Yellow to brown solid |
Hill Formula | C₂₆H₂₄F₃N₇O₃S |
Chemical formula | C₂₆H₂₄F₃N₇O₃S |
Reversible | Y |
Quality Level | MQ100 |
Biological Information | |
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Primary Target | GLS1 |
Primary Target IC<sub>50</sub> | 23 nM & 28 nM, respectively, using murine kidney and brain homogenates |
Purity | ≥97% by HPLC |
Physicochemical Information | |
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Cell permeable | Y |
Packaging Information | |
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Packaged under inert gas | Packaged under inert gas |
Global Trade Item Number | |
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Catalogue Number | GTIN |
5.33717.0001 | 04055977286656 |