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05-23-3800 Endothelin 1, Human and Porcine - CAS 117399-94-7 - Calbiochem

Overview

Key Spec Table

CAS #Empirical Formula
117399-94-7C₁₀₉H₁₅₉N₂₅O₃₂S₅

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      05-23-3800-0.5MG
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          05-23-3800-1MG
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              Description
              OverviewA 21-amino acid polypeptide with potent vasoconstrictive action. Produces convulsions, arterial hypertension, and metabolic activation of periventricular white and gray matter. Its effects are mediated via L-type Ca2+ channels. Reported to activate phospholipase C in fibroblasts expressing ETA receptors.
              Catalogue Number05-23-3800
              Brand Family Calbiochem®
              SynonymsET-1, CSCSSLMDKECVYFCHLDIIW
              References
              ReferencesCesari, M., et al. 1996. Am. Heart J. 132, 1236.
              Gresser, O., et al 1996. Biochem. Biophys. Res. Commun. 224, 169.
              Murata, S., et al. 1995. J. Pharmacol. Exp. Ther. 274, 1524.
              Hexum, T.D., et al. 1990. Biochem. Biophys. Res. Commun. 167, 294.
              Itoh, Y., et al. 1988. FEBS Lett. 231, 440.
              Yanagisawa, M., et al. 1988. Nature 332, 411.
              Product Information
              CAS number117399-94-7
              ATP CompetitiveN
              FormWhite to off-white solid
              FormulationSupplied as an acetate salt.
              Hill FormulaC₁₀₉H₁₅₉N₂₅O₃₂S₅
              Chemical formulaC₁₀₉H₁₅₉N₂₅O₃₂S₅
              ReversibleN
              Sold on the basis of peptide contentY
              Quality LevelMQ100
              Biological Information
              Primary TargetPotent vasoconstrictive action
              Purity≥96% by HPLC
              Physicochemical Information
              Cell permeableN
              Peptide ContentY
              Peptide SequenceH-Cys¹-Ser-Cys³-Ser-Ser-Leu-Met-Asp-Lys-Glu-Cys¹¹-Val-Tyr-Phe-Cys¹⁵-His-Leu-Asp-Ile-Ile-Trp-OH (disulfide bonds: 1 → 15; 3 → 11)
              Storage and Shipping Information
              Ship Code Ambient Temperature Only
              Toxicity Standard Handling
              Storage -20°C
              Protect from Moisture Protect from moisture
              Do not freeze Ok to freeze
              Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 weeks at -20°C.
              Global Trade Item Number
              Catalogue Number GTIN
              05-23-3800-0.1MG 04055977226775
              05-23-3800-0.5MG 04055977226782
              05-23-3800-1MG 04055977226799