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324411
Sigma-AldrichDynamin Inhibitor II, MiTMAB - CAS 1119-97-7 - Calbiochem
The Dynamin Inhibitor II, MiTMAB, also referenced under CAS 1119-97-7, controls the biological activity of Dynamin. This small molecule/inhibitor is primarily used for Membrane applications.
More>>The Dynamin Inhibitor II, MiTMAB, also referenced under CAS 1119-97-7, controls the biological activity of Dynamin. This small molecule/inhibitor is primarily used for Membrane applications. Less<<
MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
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Description
Overview
A cell-permeable cationic surfactant that reversibly inhibits dynamin GTPase activity (IC50 = 3.15 µM) by targeting the PH domain and interfering with phospholipid binding. Shown to block dynamin I-dependent SVE (synaptic vesicle endocytosis) in rat brain synaptosomes and dynamin II-dependent RME (receptor-mediated endocytosis) in non-neuronal HeLa, A431, and COS-7 cells. Inhibition is competitive with respect to PS and noncompetitive with respect to GTP.
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing, gloves and eye/face protection. In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Product Usage Statements
Storage and Shipping Information
Ship Code
Ambient Temperature Only
Toxicity
Corrosive
Hazardous Materials Attention:
Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage
+2°C to +8°C
Hygroscopic
Hygroscopic
Do not freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas
Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number
GTIN
324411-500MG
04055977197174
Documentation
Dynamin Inhibitor II, MiTMAB - CAS 1119-97-7 - Calbiochem MSDS
Dynamin Inhibitor II, MiTMAB - CAS 1119-97-7 - Calbiochem Certificates of Analysis
Title
Lot Number
324411
References
Reference overview
Quan, A., et al. 2007. Mol. Pharmacol.72, 1425. Hill, T.A., et al. 2004. Bioorg. Med. Chem. Lett.14, 3275.
Data Sheet
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
A cell-permeable cationic surfactant that reversibly inhibits dynamin GTPase activity (IC50 = 3.15 µM) by targeting the PH domain and interfering with phospholipid binding. Shown to block dynamin I-dependent SVE (synaptic vesicle endocytosis) in rat brain synaptosomes and dynamin II-dependent RME (receptor-mediated endocytosis) in non-neuronal HeLa, A431, and COS-7 cells. Inhibition is competitive with respect to PS and noncompetitive with respect to GTP.
Form
White solid
Intert gas (Yes/No)
Packaged under inert gas
CAS number
1119-97-7
Chemical formula
C₁₇H₃₈NBr
Purity
≥99% by Titration
Solubility
DMSO (10 mg/ml) or H₂O (100 mg/ml)
Storage
+2°C to +8°C
Hygroscopic
Do Not Freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity
Corrosive
Merck USA index
14, 6336
References
Quan, A., et al. 2007. Mol. Pharmacol.72, 1425. Hill, T.A., et al. 2004. Bioorg. Med. Chem. Lett.14, 3275.
