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263275 Desmosine

A novel quaternary pyridinium poly-amino acid present in elastin.

Desmosine MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
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263275
  
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      Overview

      Replacement Information
      Description
      OverviewA novel quaternary pyridinium poly-amino acid present in elastin. Suggested to be responsible for the cross-linking of elastin leading to the formation of insoluble fibers. Urinary excretion of desmosine is a useful indicator of elastin breakdown resulting from increased elastase activity.
      Catalogue Number263275
      Brand Family Calbiochem®
      References
      ReferencesAkagawa, M., and Suyama, K. 2000. Connect. Tissue Res. 41, 131.
      Bode, D.C., et al. 2000. Pulm. Pharmacol. Therap. 13, 175.
      Viglio, S., et al. 2000. Eur. Respir. J. 15, 1039.
      Davis, N.R., and Anwar, R.A. 1970. J. Am. Chem. Soc. 92, 3778.
      Thomas, J., et al. 1963. Nature 200, 651.
      Product Information
      ATP CompetitiveN
      FormLyophilized
      Hill FormulaC₂₄H₃₉N₅O₈
      Chemical formulaC₂₄H₃₉N₅O₈
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetCross-linking of elastin
      Purity≥99% by TLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      263275 0

      Documentation

      Desmosine MSDS

      Title

      Safety Data Sheet (SDS) 

      Desmosine Certificates of Analysis

      TitleLot Number
      263275

      References

      Reference overview
      Akagawa, M., and Suyama, K. 2000. Connect. Tissue Res. 41, 131.
      Bode, D.C., et al. 2000. Pulm. Pharmacol. Therap. 13, 175.
      Viglio, S., et al. 2000. Eur. Respir. J. 15, 1039.
      Davis, N.R., and Anwar, R.A. 1970. J. Am. Chem. Soc. 92, 3778.
      Thomas, J., et al. 1963. Nature 200, 651.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision15-June-2008 RFH
      DescriptionA novel quaternary pyridinium poly-amino acid present in elastin. Suggested to be responsible for the cross-linking of elastin leading to the formation of insoluble fibers. Urinary excretion of desmosine is a useful indicator of elastin breakdown resulting from increased elastase activity. Absorption max: 268 nm.
      FormLyophilized
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₂₄H₃₉N₅O₈
      Structure formulaStructure formula
      Purity≥99% by TLC
      SolubilityH₂O (10 mg/ml)
      Storage Protect from light
      -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesAkagawa, M., and Suyama, K. 2000. Connect. Tissue Res. 41, 131.
      Bode, D.C., et al. 2000. Pulm. Pharmacol. Therap. 13, 175.
      Viglio, S., et al. 2000. Eur. Respir. J. 15, 1039.
      Davis, N.R., and Anwar, R.A. 1970. J. Am. Chem. Soc. 92, 3778.
      Thomas, J., et al. 1963. Nature 200, 651.