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260930 DNA Polymerase Sliding Clamp Inhibitor, RU7

The DNA Polymerase Sliding Clamp Inhibitor, RU7, also referenced under CAS 355400-87-2, controls the biological activity of E. coli DNA polymerase III. This small molecule/inhibitor is primarily used for Cell Structure applications.

DNA Polymerase Sliding Clamp Inhibitor, RU7 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: E. coli Pol III/β-clamp Interaction Inhibitor

260930
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
355400-87-2C₁₄H₁₁Br₂NO₅S₂

Pricing & Availability

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260930-10MG
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      Description
      Overview

      This product has been discontinued.





      A 2-thio-thiazolidinone compound that binds the peptide-binding pocket of E. coli β-clamp and disrupts E. coli DNA polymerase III binding to β-clamp, but not the binding of Pol C to the β-clamp of the gram-positive Streptococcus pyogenes species. Shown to selectively inhibit the polymerase activity of E. coli Pol III (Ki = 10 µM) over Pol II and IV in β-dependent replicase assays, while exhibiting little effect toward the β-independent activity of E. coli Pol I Klenow fragment or the yeast PCNA-dependent Pol δ activity of the Saccharomyces cereviase species.
      Catalogue Number260930
      Brand Family Calbiochem®
      SynonymsE. coli Pol III/β-clamp Interaction Inhibitor
      References
      ReferencesGeorgescu, R.E., et al. 2008. Proc. Natl. Acad. Sci. USA 105, 11116.
      Product Information
      CAS number355400-87-2
      FormYellow solid
      Hill FormulaC₁₄H₁₁Br₂NO₅S₂
      Chemical formulaC₁₄H₁₁Br₂NO₅S₂
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥95% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°:C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      260930-10MG 04053252041334

      Documentation

      DNA Polymerase Sliding Clamp Inhibitor, RU7 MSDS

      Title

      Safety Data Sheet (SDS) 

      DNA Polymerase Sliding Clamp Inhibitor, RU7 Certificates of Analysis

      TitleLot Number
      260930

      References

      Reference overview
      Georgescu, R.E., et al. 2008. Proc. Natl. Acad. Sci. USA 105, 11116.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision06-April-2011 RFH
      SynonymsE. coli Pol III/β-clamp Interaction Inhibitor
      DescriptionA 2-thio-thiazolidinone compound that binds the peptide-binding pocket of E. coli β-clamp and disrupts E. coli DNA polymerase III binding to β-clamp, but not the binding of Pol C to the β-clamp of the gram-positive Streptococcus pyogenes species. Shown to selectively inhibit the polymerase activity of E. coli Pol III (Ki = 10 µM) over Pol II & IV in β-dependent replicase assays, while exhibiting little effect toward the β-independent activity of E. coli Pol I Klenow fragment or the yeast PCNA-dependent Pol δ activity of the Saccharomyces cereviase species.
      FormYellow solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number355400-87-2
      Chemical formulaC₁₄H₁₁Br₂NO₅S₂
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°:C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesGeorgescu, R.E., et al. 2008. Proc. Natl. Acad. Sci. USA 105, 11116.