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204896 Complement C8, Human

Complement C8, Human, CAS 80295-58-5, is a native glycoprotein composed of three non-identical subunits of 64, (α), 64 (β), and 22 kDa (γ).

Complement C8, Human MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
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204896
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Overview

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204896-250UG
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      		 Plastic ampoule 250 μg
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      Description
      OverviewNative, human C8 complement component. Glycoprotein composed of three non-identical subunits of M.W. 64 kDa (α), 64 kDa (β), and 22 kDa (γ). Present in normal human serum at 55 µg/ml. On activation of complement via either the classical or alternative pathway, C5 is cleaved into C5a and C5b fragments. The nascent C5b fragment binds to C6, C7, and C8 resulting in formation of the C5b-8 complex on target surfaces. Each membrane-bound, hydrophobic C5b-8 complex combines with three to six C9 molecules to complete the assembly of the lytic C5b-9 complement membrane attack complex (MAC).
      Catalogue Number204896
      Brand Family Calbiochem®
      References
      ReferencesSteckel, E.W., et al. 1980. J. Biol. Chem. 255, 11997.
      Petersen, B.H., et al. 1976. J. Clin. Invest. 57, 283.
      Product Information
      CAS number80295-58-5
      FormLiquid
      FormulationIn PBS, pH 7.2.
      Quality LevelMQ200
      Applications
      Biological Information
      Purity≥85% by SDS-PAGE
      SourcePrepared from serum that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
      Specific Activity≥150,000 C₈H₅0 units/mg
      Concentration Label Please refer to vial label for lot-specific concentration
      Physicochemical Information
      ContaminantsIgG, IgA, IgM, albumin, C3, C4, C7, C9: ≤trace amounts
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Standard Handling
      Storage ≤ -70°C
      Avoid freeze/thaw Avoid freeze/thaw
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      204896-250UG 04055977219845

      Documentation

      Complement C8, Human MSDS

      Title

      Safety Data Sheet (SDS) 

      Complement C8, Human Certificates of Analysis

      TitleLot Number
      204896

      References

      Reference overview
      Steckel, E.W., et al. 1980. J. Biol. Chem. 255, 11997.
      Petersen, B.H., et al. 1976. J. Clin. Invest. 57, 283.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision21-August-2009 RFH
      DescriptionNative, human C8 complement component. Glycoprotein composed of three non-identical subunits of M.W. 64,000 (α), 64,000 (β), and 22,000 (γ). Present in normal human serum at 55 µg/ml. On activation of complement via either the classical or alternative pathway, C5 is cleaved into C5a and C5b fragments. The nascent C5b fragment binds to C6, C7, and C8, resulting in formation of C5b-8 complex on target surfaces. Each membrane-bound, hydrophobic C5b-8 complex combines with three to six C9 molecules to complete the assembly of the lytic C5b-9 complement membrane attack complex (MAC).
      FormLiquid
      FormulationIn PBS, pH 7.2.
      Concentration Label Please refer to vial label for lot-specific concentration
      SourcePrepared from serum that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
      CAS number80295-58-5
      Purity≥85% by SDS-PAGE
      ContaminantsIgG, IgA, IgM, albumin, C3, C4, C7, C9: ≤trace amounts
      Specific activity≥150,000 C₈H₅0 units/mg
      Storage Avoid freeze/thaw
      ≤ -70°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
      Toxicity Standard Handling
      ReferencesSteckel, E.W., et al. 1980. J. Biol. Chem. 255, 11997.
      Petersen, B.H., et al. 1976. J. Clin. Invest. 57, 283.