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219677 CFTR Inhibitor IV, PPQ-102 - CAS 931706-15-9 - Calbiochem

CFTR Inhibitor IV, PPQ-102, CAS 931706-15-9, is a cell-permeable inhibitor of CFTR-mediated chloride current in a reversible and voltage-independent manner.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 7,9-Dimethyl-11-phenyl-6-(5-methylfuran-2-yl)-5,6-dihydro-pyrimido-[4ʹ,5ʹ-3,4]pyrrolo[1,2-a]quinoxaline-8,10-(7H,9H)-dione, Cystic Fibrosis Transmembrane Conductance Regulator Inhibitor IV

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219677
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
931706-15-9C₂₆H₂₂N₄O₃

Pricing & Availability

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219677-10MG
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      Description
      OverviewA cell-permeable pyrimido-pyrrolo-quinoxalinedione (PPQ) compound that targets the intracellular nucleotide binding domain(s) of CFTR and inhibits CFTR-mediated chloride current in a reversible and voltage-independent manner. Single channel recordings of CFTR-expressing FRT cells upon forskolin (Cat. No. 344270) and IBMX (Cat. No. 410957) stimulation indicate that the nature of PPQ-102 inhibition is due to a stabilization of the channels in a closed state (7.8- vs. 0.4-fold increase of mean channel close vs. open time, respectively, with 1 µM PPQ-102). PPQ-102 at 5 µM is shown to completely prevent Sp-8-Br-cAMP- (Cat. No. 116818) induced cysts formation and reduce the size of preformed cysts in an ex vivo murine neonatal kidney organ culture.
      Catalogue Number219677
      Brand Family Calbiochem®
      Synonyms7,9-Dimethyl-11-phenyl-6-(5-methylfuran-2-yl)-5,6-dihydro-pyrimido-[4ʹ,5ʹ-3,4]pyrrolo[1,2-a]quinoxaline-8,10-(7H,9H)-dione, Cystic Fibrosis Transmembrane Conductance Regulator Inhibitor IV
      References
      ReferencesTradtrantip, L., et al. 2009. J. Med. Chem. 52, 6447.
      Product Information
      CAS number931706-15-9
      FormWhite crystalline solid
      Hill FormulaC₂₆H₂₂N₄O₃
      Chemical formulaC₂₆H₂₂N₄O₃
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationCFTR Inhibitor IV, PPQ-102, CAS 931706-15-9, is a cell-permeable inhibitor of CFTR-mediated chloride current in a reversible and voltage-independent manner.
      Biological Information
      Purity≥95% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      219677-10MG 04055977200959

      Documentation

      CFTR Inhibitor IV, PPQ-102 - CAS 931706-15-9 - Calbiochem MSDS

      Title

      Safety Data Sheet (SDS) 

      CFTR Inhibitor IV, PPQ-102 - CAS 931706-15-9 - Calbiochem Certificates of Analysis

      TitleLot Number
      219677

      References

      Reference overview
      Tradtrantip, L., et al. 2009. J. Med. Chem. 52, 6447.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision05-April-2011 RFH
      Synonyms7,9-Dimethyl-11-phenyl-6-(5-methylfuran-2-yl)-5,6-dihydro-pyrimido-[4ʹ,5ʹ-3,4]pyrrolo[1,2-a]quinoxaline-8,10-(7H,9H)-dione, Cystic Fibrosis Transmembrane Conductance Regulator Inhibitor IV
      DescriptionA cell-permeable pyrimido-pyrrolo-quinoxalinedione (PPQ) compound that targets the intracellular nucleotide binding domain(s) of CFTR and inhibits CFTR-mediated chloride current in a reversible and voltage-independent manner. Single channel recordings of CFTR-expressing FRT cells upon forskolin (Cat. No. 344270) and IBMX (Cat. No. 410957) stimulation indicate that the nature of PPQ-102 inhibition is due to a stabilization of the channels in a closed state (7.8- vs. 0.4-fold increase of mean channel close vs. open time, respectively, with 1 µM PPQ-102). PPQ-102 at 5 µM is shown to completely prevent Sp-8-Br-cAMP- (Cat. No. 116818) induced cysts formation and reduce the size of preformed cysts in an ex vivo murine neonatal kidney organ culture.
      FormWhite crystalline solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number931706-15-9
      Chemical formulaC₂₆H₂₂N₄O₃
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (5 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesTradtrantip, L., et al. 2009. J. Med. Chem. 52, 6447.