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ABN253 Anti-PTGDS Antibody

Detect the PTGDS protein using this Anti-PTGDS validated for use in WB & IHC.

Anti-PTGDS Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Developmental Signaling Gene Symbol: PTGDS, PDS UniProt Number: P41222
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ABN253
100 µg  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, Rhesus MacaqueWB, IHCRbPurifiedPolyclonal Antibody
      Description
      Catalogue NumberABN253
      DescriptionAnti-PTGDS Antibody
      Alternate Names
      • Prostaglandin-H2 D-isomerase
      • Beta-trace protein
      • Cerebrin-28
      • Glutathione-independent PGD synthase
      • Lipocalin-type prostaglandin-D synthase
      • Prostaglandin-D2 synthase
      • PGD2 synthase
      • PGDS
      • PGDS2
      Background InformationProstaglandin-H2 D-isomerase (PTGDS), also known the Lipocalin-type prostaglandin-D synthase, catalyzes the conversion of PGH2 to PGD2. PTGDS serves both as a PGD2-synthesizing enzyme and as an extracellular transporter of various lipophilic small molecules. It is the only enzyme in the lipocalin type protein family, members of which mainly act as binding proteins. It has been shown to bind various small, lipophilic compounds such as retinoic acid, biliverdin, bilirubin, retinoic acid, and thyroid hormone and may act as a scavenger for harmful hydrophobic molecules. In cells it is localized in the endoplasm reticulum, golgi apparatus, cell membrane, and is also secreted. PTGDS is involved in several central nervous system functions, such as sedation, pain regulation and non-rapid eye movement sleep. It is suggested to be involved in development and maintenance of the blood-brain, blood-retina, and blood-aqueous humor barriers and may also play a role in maturation and maintenance of the central nervous system.
      References
      Product Information
      FormatPurified
      Control
      • Human testis tissue lysate
      PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationDetect the PTGDS protein using this Anti-PTGDS validated for use in WB & IHC.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      Application NotesImmunohistochemistry Analysis: 1:100 dilution from a representative lot detected PTGDS in human pons/midbrain and human cardiac myocytes.
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to human PTGDS.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      Species Reactivity
      • Human
      • Rhesus Macaque
      Species Reactivity NoteDemonstrated to react with Human. Predicted to react with Rhesus Macaque based on 100% sequence homology. Other homologies: Feline (92% sequence homology), Canine (83% sequence homology), Mouse (75% sequence homology), no homology to Rat detected.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • PTGDS
      • PDS
      Purification MethodProtein A Purfied
      UniProt Number
      Molecular Weight~30 kDa observed
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in human testis tissue lysate.

      Western Blot Analysis: 0.2 µg/mL of this antibody detected PTGDS in 10 µg of human testis tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      ABN253 04053252830563

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies