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AB10130 Anti-NR1D1 (Rev-ErbA α) Antibody

Anti-NR1D1 (Rev-ErbA α) Antibody is a Rabbit Polyclonal Antibody for detection of NR1D1 (Rev-ErbA α) also known as V-erbA-related protein EAR-1 & has been validated in WB.

Anti-NR1D1 (Rev-ErbA α) Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Epigenetics & Nuclear Function Research Sub-Category: Transcription Factors Gene Symbol: EAR1, HREV, Rev-ErbAalpha , Rev-erbA-alpha , THRA1, THRAL, ear-1, hRev UniProt Number: P20393
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AB10130
100 µg  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWBRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberAB10130
      DescriptionAnti-NR1D1 (Rev-ErbA α) Antibody
      Alternate Names
      • V-erbA-related protein EAR-1
      • nuclear receptor subfamily 1, group D, member 1
      • thyroid hormone receptor, alpha-like
      Background InformationRev-ErbA alpha (NR1D1 or nuclear receptor subfamily 1, group D, member 1), is a member of the Rev-ErbA family of nuclear receptors and is a transcriptional repressor. In mammals, Rev-Erbα is highly expressed in the liver, skeletal muscle, adipose tissue, and the brain, participating in the development and circadian regulation of these tissues. Rev-Erbα regulates gene transcription by directly binding to target response elements (RevREs), comprises an A/T-rich flank followed by AGGTCA. Rev-Erbα mediates repression by recruiting the corepressor N-CoR, which then activates the histone deacetylase (HDAC) 3. A number of target genes has been identified for Rev-Erbα, including the lipoproteins ApoA1 and ApoCIII, hydratase dehydrogenase, the circadian factor BMAL, and the anti-fibrinolytic factor PAI-1. Many of these genes are coordinately regulated by Rev-erbα and the RAR-related orphan receptor RORα, which share the same response elements but exert opposite effects on gene transcription. Crosstalk between Rev-Erbα and RORα likely acts to fine-tune of their target physiologic networks, such as circadian rhythms, metabolic homeostasis, and inflammation.
      References
      Product Information
      FormatAffinity Purified
      Control
      • A431 cell lysate
      PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-glycine, pH 7.4, 0.150 mM NaCl and 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-NR1D1 (Rev-ErbA α) Antibody is a Rabbit Polyclonal Antibody for detection of NR1D1 (Rev-ErbA α) also known as V-erbA-related protein EAR-1 & has been validated in WB.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to residues surrounding the area near the N-terminus region of NR1D1.
      EpitopeNear N-terminus
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityThis antibody recognizes NR1D1 near the N-terminus.
      Species Reactivity
      • Human
      Species Reactivity NoteProven to react with human.
      Mouse and rat (92% sequence homology).
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • EAR1
      • HREV
      • Rev-ErbAalpha
      • Rev-erbA-alpha
      • THRA1
      • THRAL
      • ear-1
      • hRev
      Purification MethodAffinity Purfied
      UniProt Number
      UniProt SummaryFUNCTION: Functions as a constitutive transcriptional repressor. Possible receptor for triiodothyronine.
      SUBUNIT STRUCTURE: Interacts with C1D By similarity.
      SUBCELLULAR LOCATION: Nucleus Potential.
      TISSUE SPECIFICITY: Expressed in all tissues and cell lines examined. Expressed at high levels in some squamous carcinoma cell lines.
      DOMAIN: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal steroid-binding domain.
      SEQUENCE SIMILARITIES: Belongs to the nuclear hormone receptor family. NR1 subfamily.
      Contains 1 nuclear receptor DNA-binding domain.
      Molecular Weight~67 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in A431 cell lysate.
      Western Blot Analysis: 1 µg/mL of this antibody detected NR1D1 in 10 µg of A431 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain refrigerated at 2-8°C for 1 year from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      AB10130 04053252620393

      Documentation

      Anti-NR1D1 (Rev-ErbA α) Antibody MSDS

      Title

      Safety Data Sheet (SDS) 

      Anti-NR1D1 (Rev-ErbA α) Antibody Certificates of Analysis

      TitleLot Number
      Anti-NR1D1 (Rev-ErbA ) - NG1630774 NG1630774
      Anti-NR1D1 (Rev-ErbA ) - NG1905694 NG1905694
      Anti-NR1D1 (Rev-ErbA α) - 2389523 2389523
      Anti-NR1D1 (Rev-ErbA α) - 2395704 2395704
      Anti-NR1D1 (Rev-ErbA α) - 2428871 2428871
      Anti-NR1D1 (Rev-ErbA α) - 2459519 2459519
      Anti-NR1D1 (Rev-ErbA α) - 3703185 3703185
      Anti-NR1D1 (Rev-ErbA α) -2763858 2763858
      Anti-NR1D1 (Rev-ErbA α) -2859500 2859500
      Anti-NR1D1 (Rev-ErbA α) Polyclonal Antib 2978906

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies