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MABS2190-25UG Anti-Extrahepatic biliary cells Antibody, clone hGB10

Anti-Extrahepatic biliary cells, clone hGB10, Cat. No. MABS2190, is a mouse monoclonal antibody that detects subset of gallbladder mucosal epitheliums with apical bias and is tested in Immunofluorescence and Immunohistochemistry (Paraffin).

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MABS2190-25UG
25 μg  
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      Overview

      Replacement Information
      Description
      Catalogue NumberMABS2190-25UG
      DescriptionAnti-Extrahepatic biliary cells Antibody, clone hGB10
      Alternate Names
      • EHBC
      • Gallbladder cells
      Background InformationThe gallbladder is a small, distensible pouch-like organ that concentrates and stores bile produced by the liver that helps break down dietary fats. Bile flows out of the liver via hepatic ducts that join with the cystic duct, which conveys bile to and from the gall bladder. Gallbladder is derived from the foregut endoderm during embryonic development. In an un-distended state, its mucosa appears to be thrown into many folds. Its lumen is lined with a high columnar epithelium. This epithelial layer rests on a highly vascularized lamina propria. The biliary epithelium shows a morphological heterogeneity that is strictly associated with a variety of functions performed at the different levels of the biliary tree. These epithelial cells are also involved in absorption of water and inorganic salts and help to concentrate bile. The connective tissue wall of gallbladder contains abundant elastic fibers and layers of smooth muscles that run obliquely. Between the smooth muscle layers and serosa lies a thick layer subserosal layer of connective tissue. The availability of antibodies that preferentially mark cell populations within the extrahepatic biliary system are useful for identification and classification of gallbladder cells in relation to bile physiology, gallstone formation, cell plasticity and renewal, metaplasia, and tumor formation. Clone hBG10 is reported to specifically detect a subset of gallbladder mucosal epithelium with apical bias and peribiliary glands. (Ref.: Galivo, FH., et al. (2015). Stem Cell Res. 15(1); 172-181).
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal antibody IgG1 in 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide
      Quality LevelMQ200
      Applications
      ApplicationAnti-Extrahepatic biliary cells, clone hGB10, Cat. No. MABS2190, is a mouse monoclonal antibody that detects subset of gallbladder mucosal epitheliums with apical bias and is tested in Immunofluorescence and Immunohistochemistry (Paraffin).
      Key Applications
      • Immunohistochemistry (Paraffin)
      • Immunofluorescence
      Application NotesTested Applications

      Immunofluorescence Analysis: A representative lot detected Extrahepatic biliary cells in Immunofluorescence applications (Galivo, F.H., et al. (2015). Stem Cell Res. 15(1):172-81).

      Note: Actual optimal working dilutions must be determined by end user as specimens, and experimental conditions may vary with the end user
      Biological Information
      ImmunogenExtrahepatic human biliary cells
      EpitopeUnknown
      ClonehGB10
      Concentration0.5 mg/ml. Please refer to guidance on suggested starting dilutions and/or titers per application and sample type.
      HostMouse
      SpecificityClone hGB10 is a mouse monoclonal antibody that detects a subset of mucosal epithelium with apical bias in human gallbladder.
      IsotypeIgG1κ
      Species Reactivity
      • Human
      Species Reactivity NoteHuman.
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Purification MethodProtein G purified
      UniProt Number
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Immunohistochemistry (Paraffin) in human gallbladder tissue sections.

      Immunohistochemistry (Paraffin) Analysis: A 1:50 dilution of this antibody detected a subset of mucosal epithelium with apical bias and peribiliary glands in human gallbladder tissue sections.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsRecommend storage at +2°C to +8°C. For long term storage antibodies can be kept at -20°C. Avoid repeated freeze-thaws.
      Packaging Information
      Material Size25 μg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      MABS2190-25UG 04065267463742