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07-1386 Anti-Connective Tissue Growth Factor Antibody

Anti-Connective Tissue Growth Factor Antibody detects level of Connective Tissue Growth Factor & has been published & validated for use in WB.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Signaling Research Sub-Category: Growth Factors & Receptors Gene Symbol: CTGF, CCN2, HCS24, IGFBP8, NOV2 UniProt Number: P29279
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07-1386
100 µg  
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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWBGtPurifiedPolyclonal Antibody
      Description
      Catalogue Number07-1386
      DescriptionAnti-Connective Tissue Growth Factor Antibody
      Alternate Names
      • Hypertrophic chondrocyte-specific protein 24
      • connective tissue growth factor
      • insulin-like growth factor-binding protein 8
      Background InformationConnective Tissue Growth Factor (CTGF) is a member of the CNN family of growth factors that are characterized as having cysteine-rich peptides with four specific domains. CTGF was originally identified in endothelial cells as a significant chemotactic and mitogenic factor. Research has revealed CTGF to have several biological properties which include chemotaxis, cell proliferation, promotion of adhesion and the formation of extracellular matrix. It is also necessary for such biological processes as wound healing, scar formation, fibrosis, embryogenesis and angiogenesis. In its role as an inducer of angiogenesis, CTGF has been associated with vascular endothelial growth factor (VEGF). As a result of its pro-fibrotic properties, CTGF is thought to be a promising target for therapy in conditions involving pathological fibrosis such as chronic fibrotic disease, chronic kidney disease and proliferative diabetic retinopathy (PDR). Cell types found to express CTGF are endothelial cells, fibroblasts and vascular smooth-muscle cells.
      References
      Product Information
      FormatPurified
      Control
      • Untreated and TGFb1 treated NRK cell lysates
      PresentationPurified goat polyclonal in buffer containing Tris-Glycine pH 8.0 with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-Connective Tissue Growth Factor Antibody detects level of Connective Tissue Growth Factor & has been published & validated for use in WB.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenRecombinant protein corresponding to the mature chain of human Connective tissue growth factor.
      EpitopeMature chain
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostGoat
      SpecificityThis antibody recognizes the mature chain of Connective tissue growth factor.
      Species Reactivity
      • Human
      Species Reactivity NoteDemonstrated to react with Human.
      Primate (98% sequence homolgy). Monkey (97% sequence homology). Porcine and Bovine (93% sequence homology). Rat and mouse (91% sequence homology).
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by this gene is a mitogen that is secreted by vascular endothelial cells. The encoded protein plays a role in chondrocyte proliferation and differentiation, cell adhesion in many cell types, and is related to platelet-derived growth factor. Certain polymorphisms in this gene have been linked with a higher incidence of systemic sclerosis. [provided by RefSeq].
      Gene Symbol
      • CTGF
      • CCN2
      • HCS24
      • IGFBP8
      • NOV2
      Purification MethodProtein G Purified
      UniProt Number
      UniProt SummaryFUNCTION: Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis.

      SUBCUNIT STRUCTURE: Monomer.

      SUBCELLULAR LOCATION: Secreted › extracellular space › extracellular matrix By similarity. Secreted By similarity.

      SEQUENCE SIMILARITIES: Belongs to the CCN family.

      Contains 1 CTCK (C-terminal cystine knot-like) domain.

      Contains 1 IGFBP N-terminal domain.

      Contains 1 TSP type-1 domain.

      Contains 1 VWFC domain.
      Molecular WeightIn Western Blot, full length CTGF is observed at 38 kDa and CTGF N&C domain is observed at 19 kDa.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in untreated and TGFb1 treated NRK cell lysates.

      Western Blot Analysis: 5 µg/mL of this antibody detected Connective tissue growth factor on 10 µg of untreated and TGFb1 treated NRK cell lysates.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      07-1386 04053252411090

      Documentation

      Anti-Connective Tissue Growth Factor Antibody MSDS

      Title

      Safety Data Sheet (SDS) 

      Anti-Connective Tissue Growth Factor Antibody Certificates of Analysis

      TitleLot Number
      Anti-Connective Tissue Growth Factor 3075659
      Anti-Connective Tissue Growth Factor 2474951
      Anti-Connective Tissue Growth Factor - 2201497 2201497
      Anti-Connective Tissue Growth Factor - 3990663 3990663
      Anti-Connective Tissue Growth Factor - NG1928923 NG1928923
      Anti-Connective Tissue Growth Factor - NRG1719645 NRG1719645
      Anti-Connective Tissue Growth Factor -2568178 2568178
      Anti-Connective Tissue Growth Factor -2786964 2786964

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies