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MABF94 Anti-BDCA-2 Antibody, clone 10E6.1

Detect BDCA-2 using this Anti-BDCA-2 Antibody, clone 10E6.1 validated for use in Western Blotting & IHC.

Anti-BDCA-2 Antibody, clone 10E6.1 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Inflammation & Immunology Research Sub-Category: Immunoglobulins & Immunology Gene Symbol: CLEC4C, BDCA2, CLECSF11, CLECSF7, DLEC, HECL UniProt Number: Q8WTT0
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MABF94
100 µg  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWB, IHCMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABF94
      DescriptionAnti-BDCA-2 Antibody, clone 10E6.1
      Alternate Names
      • C-type lectin domain family 4 member C
      • Blood dendritic cell antigen 2
      • BDCA-2
      • C-type lectin superfamily member 7
      • Dendritic lectin
      • CD303
      Background InformationBlood dendritic cell antigen 2 (BDCA-2;CD303) is a type II C-type lectin that is expressed on plasmacytoid dendritic cells (PDC), a subset of immature dendritic cells found in lymphoid and nonlymphoid tissues. BDCA-2 is critically involved in both adaptive and innate immune responses. It is involved in the recognition and internalization of pathogens, but inhibits TLR6 signaling and INF-1 production, in PDC cells, possibly through signaling of the BCR-like signalosome. PDC signaling has been linked to multiple inflammatory diseases such as granulomatous lymphadenitis.
      References
      Product Information
      FormatPurified
      HS Code3002 15 90
      Control
      • Recombinant BDCA-2 protein
      PresentationPurified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationDetect BDCA-2 using this Anti-BDCA-2 Antibody, clone 10E6.1 validated for use in Western Blotting & IHC.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      Application NotesImmunohistochemistry Analysis: A 1:50 dilution from a representative lot detected BDCA-2 in human tonsil tissue.
      Biological Information
      ImmunogenGST-tagged recombinant protein corresponding to human BDCA-2.
      Clone10E6.1
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      IsotypeIgG1κ
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • CLEC4C
      • BDCA2
      • CLECSF11
      • CLECSF7
      • DLEC
      • HECL
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight~33 kDa observed. Uncharacterized bands appear at ~25 and ~31 kDa in some lysates.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in recombinant BDCA-2 protein.

      Western Blot Analysis: 1 µg/mL of this antibody detected BDCA-2 on 10 µg of recombinant BDCA-2 protein.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      MABF94 04053252691959

      Documentation

      Anti-BDCA-2 Antibody, clone 10E6.1 MSDS

      Title

      Safety Data Sheet (SDS) 

      Anti-BDCA-2 Antibody, clone 10E6.1 Certificates of Analysis

      TitleLot Number
      Anti-BDCA-2, clone 10E6.1 2480956
      Anti-BDCA-2, clone 10E6.1 - 2360028 2360028
      Anti-BDCA-2, clone 10E6.1 - 2463175 2463175
      Anti-BDCA-2, clone 10E6.1 - 2172778 2172778
      Anti-BDCA-2, clone 10E6.1 - 2201526 2201526
      Anti-BDCA-2, clone 10E6.1 - 2239643 2239643
      Anti-BDCA-2, clone 10E6.1 - 3313744 3313744
      Anti-BDCA-2, clone 10E6.1 - 3508390 3508390
      Anti-BDCA-2, clone 10E6.1 - 3698182 3698182
      Anti-BDCA-2, clone 10E6.1 - 3745548 3745548
      Show more

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies