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129876
Sigma-AldrichAmiloride, Hydrochloride - CAS 2016-88-8 - Calbiochem
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Description
Overview
An inhibitor of angiogenesis. Inhibits capillary morphogenesis completely and reversibly at approximately 130 µM. At low concentrations, acts as a potent and specific inhibitor of transmembrane Na+ entry and Na+,K+-ATPase. Also acts as an inhibitor of urokinase-type plasminogen activator (uPA). Blocks smooth muscle responses to contractile stimuli and palytoxin-induced conductance in skeletal muscle. Reduces electrical potential across tubular epithelium. At higher concentrations, blocks the Na+/H+ exchange pathway.
Catalogue Number
129876
Brand Family
Calbiochem®
Synonyms
Acid-Sensing Ion Channel Modulator I, ASIC Channel Modulator I
References
References
Knoll, A., et al. 1999. Microvasc. Res.58, 1. Swiercz, R., et al. 1999. Oncol. Rep.6, 523. Moran, A., et al. 1995. Am. J. Physiol. 268, C350. Alliegro, M.C., et al. 1993. J. Exp. Zool. 267, 245. Sugiyama, S., et al. 1988. J. Biol. Chem.263, 8215. Yoshida, K., et al. 1988. Biochem. Biophys. Res. Commun.154, 101. Sariban-Sotorabay, S., and Benos, D.J. 1986. Am. J. Physiol.250, C175.
130 µM inhibiting capillary morphogenesis completely and reversibly
Purity
≥98% by HPLC
Physicochemical Information
Cell permeable
N
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECS
UQ2275500
Safety Information
R Phrase
R: 25
Toxic if swallowed.
S Phrase
S: 45-36
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible). Wear suitable protective clothing.
Product Usage Statements
Storage and Shipping Information
Ship Code
Ambient Temperature Only
Toxicity
Toxic
Hazardous Materials Attention:
Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage
+15°C to +30°C
Protect from Light
Protect from light
Hygroscopic
Hygroscopic
Do not freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze (-20°C). Aqueous stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number
GTIN
129876-100MG
04055977222289
Documentation
Amiloride, Hydrochloride - CAS 2016-88-8 - Calbiochem MSDS
Amiloride, Hydrochloride - CAS 2016-88-8 - Calbiochem Certificates of Analysis
Title
Lot Number
129876
References
Reference overview
Knoll, A., et al. 1999. Microvasc. Res.58, 1. Swiercz, R., et al. 1999. Oncol. Rep.6, 523. Moran, A., et al. 1995. Am. J. Physiol. 268, C350. Alliegro, M.C., et al. 1993. J. Exp. Zool. 267, 245. Sugiyama, S., et al. 1988. J. Biol. Chem.263, 8215. Yoshida, K., et al. 1988. Biochem. Biophys. Res. Commun.154, 101. Sariban-Sotorabay, S., and Benos, D.J. 1986. Am. J. Physiol.250, C175.
Data Sheet
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
Revision
20-April-2009 JSW
Synonyms
Acid-Sensing Ion Channel Modulator I, ASIC Channel Modulator I
Description
An inhibitor of angiogenesis. At low concentrations, acts as a potent and specific inhibitor of transmembrane Na+ entry and Na+/H+ ATPase. Inhibits smooth muscle responses to contractile stimuli. Blocks palytoxin-induced conductance in skeletal muscle. Reduces the electrical potential across tubular epithelium. At higher concentrations, blocks the Na+/H+ exchange pathway.
Form
Off-white to yellow solid
CAS number
2016-88-8
RTECS
UQ2275500
Chemical formula
C₆H₈ClN₇O • HCl
Structure formula
Purity
≥98% by HPLC
Solubility
DMSO (5 mg/ml) or H₂O (2.5 mg/ml)
Storage
Protect from light
+15°C to +30°C
Hygroscopic
Do Not Freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze (-20°C). Aqueous stock solutions are stable for up to 6 months at -20°C.
Toxicity
Toxic
Merck USA index
14, 406
References
Knoll, A., et al. 1999. Microvasc. Res.58, 1. Swiercz, R., et al. 1999. Oncol. Rep.6, 523. Moran, A., et al. 1995. Am. J. Physiol. 268, C350. Alliegro, M.C., et al. 1993. J. Exp. Zool. 267, 245. Sugiyama, S., et al. 1988. J. Biol. Chem.263, 8215. Yoshida, K., et al. 1988. Biochem. Biophys. Res. Commun.154, 101. Sariban-Sotorabay, S., and Benos, D.J. 1986. Am. J. Physiol.250, C175.
