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100110 AAPH - CAS 2997-92-4 - Calbiochem

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      Overview

      Key Spec Table

      CAS #Empirical Formula
      2997-92-4C₈H₁₈N₆ · 2HCl
      Description
      Overview

      This product has been discontinued.



      A heat-sensitive, water-soluble, free radical initiator that induces oxidative stress by causing cellular damage associated with lipid peroxidation, protein modification, hemoglobin oxidation, and DNA strand breakage. Reported to induce apoptosis in HL-60 cells via activation of caspase-3.

      Catalogue Number100110
      Brand Family Calbiochem®
      SynonymsABAP, 2,2ʹ-Azobis-(2-amidinopropane), 2HCl, 2,2ʹ-Azobis-(2-methylpropionamidine), 2HCl
      References
      ReferencesIshika, R., et al. 2001. J. Biochem. (Tokyo) 129, 35.
      Raneva, V., et al. 2001. Lipids 36, 1111.
      Thomas, M.J., et al. 2001. Biochemistry 40, 1719.
      Kwon, H.Y., et al. 2000. Biochem. Biophys. Acta 1543, 69.
      Bassett, C.N., et al. 1999. Lipids 34, 1273.
      Viner, R.I., et al. 1997. Biochemistry 36, 7706.
      Kanno, T., et al. 1994. Free Radic. Res. 21, 223.
      Product Information
      CAS number2997-92-4
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₈H₁₈N₆ · 2HCl
      Chemical formulaC₈H₁₈N₆ · 2HCl
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationAAPH, CAS 2997-92-4, is a heat-sensitive, water-soluble, free radical initiator. Induces oxidative stress to cause lipid peroxidation, protein modification & DNA strand breakage.
      Biological Information
      Primary TargetFree radical initiator that induces oxidative stress
      Purity≥96% by titration
      Physicochemical Information
      Cell permeableN
      Safety Information according to GHS
      RTECSUE4575500
      Safety Information
      R PhraseR: 20/21/22-36/37/38-42/43

      Harmful by inhalation, in contact with skin and if swallowed.
      Irritating to eyes, respiratory system and skin.
      May cause sensitization by inhalation and skin contact.
      S PhraseS: 26-36

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing.
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful
      Storage -20°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, refrigerate (4°C). Stock solutions are stable for up to 24 h at 4°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Catalogue Number GTIN
      100110 0