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530729 AAA-ATPase Drg1 Inhibitor, Diazaborine - CAS 22959-81-5 - Calbiochem

An anti-bacterial compound that targets NAD(P)H-dependent enoyl acyl carrier protein reductase (ENR) resulting in the inhibition of bacterial fatty acid synthase.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 2-tosylbenzo[d][1,2,3]diazaborinin-1(2H)-ol, Ribosome Biogenesis Inhibitor, Diazaborine, Drg1 inhibitor

Primary Target: Drg1 AAA-ATPase
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530729
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Overview

Key Spec Table

CAS #Empirical Formula
22959-81-5C₁₄H₁₃BN₂O₃S

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      		 Glass bottle 10 mg
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      Description
      OverviewA diazaborine derivative with anti-bacterial properties against a wide range of Gram-negative bacteria. Shown to target NAD(P)H-dependent enoyl acyl carrier protein reductase (ENR), which results in the inhibition of bacterial fatty acid synthase. Blocks the maturation of ribosomal RNA for the large 60S ribosomal subunit in yeast cells by binding to the D2 domain of AAA-ATPase Drg1 (Ki = 26 µM) resulting in reduced ATP hydrolysis and release of Rip24 from pre-60S particles.

      Please note that the molecular weight for this compound is batch-specific due to variable water content.
      Catalogue Number530729
      Brand Family Calbiochem®
      Synonyms2-tosylbenzo[d][1,2,3]diazaborinin-1(2H)-ol, Ribosome Biogenesis Inhibitor, Diazaborine, Drg1 inhibitor
      References
      ReferencesLoibl, M., et al. 2014. J. Biol. Chem. 289, 3913.
      Pertschy B., et al. 2004. Mol. Cell. Biol. 24, 6476.
      Baldock, C. et al. 1998. Biochem. Pharmacol. 55, 1541.
      Grassberger M., et al. 1984. J Med Chem. 27, 947.
      Product Information
      CAS number22959-81-5
      FormWhite powder
      Hill FormulaC₁₄H₁₃BN₂O₃S
      Chemical formulaC₁₄H₁₃BN₂O₃S
      ReversibleY
      Quality LevelMQ100
      Biological Information
      Primary TargetDrg1 AAA-ATPase
      Primary Target K<sub>i</sub>26 µ
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Catalogue Number GTIN
      5.30729.0001 04055977260458