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410957 3-Isobutyl-1-methylxanthine - CAS 28822-58-4 - Calbiochem

3-Isobutyl-1-methylxanthine, CAS 28822-58-4, is a cell-permeable, non-specific inhibitor of cAMP and cGMP phosphodiesterases (IC50 = 2-50 µM).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: IBMX

Primary Target: cAMP and cGMP phosphodiesterases
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410957
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Overview

Key Spec Table

CAS #Empirical Formula
28822-58-4C₁₀H₁₄N₄O₂

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410957-1GM
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      410957-250MG
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          Description
          OverviewA cell-permeable, non-specific inhibitor of cAMP and cGMP phosphodiesterases (IC50 = 2-50 µM). Also acts as an adenosine receptor antagonist. Reported to inhibit TNF-α expression in adipocyte precursor cells.
          Catalogue Number410957
          Brand Family Calbiochem®
          SynonymsIBMX
          References
          ReferencesHube, F., et al. 1999. Horm. Metab. Res. 31, 359.
          Morgan, A.J., et al. 1993. Biochem. Pharmacol. 45, 2373.
          Scamps, F., et al. 1993. Eur. J. Pharmacol. 244, 119.
          Turner, N.C., et al. 1993. Br. J. Pharmacol. 108, 876.
          Tamura, T., et al. 1991. J. Gen. Physiol. 98, 95.
          Beavo, J.A., and Reifsnyder, D.H. 1990. Trends Pharmacol. Sci. 11, 150.
          Russell, T.R. 1979. Proc. Natl. Acad. Sci. USA 76, 4451.
          Product Information
          CAS number28822-58-4
          ATP CompetitiveN
          FormWhite solid
          Hill FormulaC₁₀H₁₄N₄O₂
          Chemical formulaC₁₀H₁₄N₄O₂
          ReversibleN
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          Application3-Isobutyl-1-methylxanthine, CAS 28822-58-4, is a cell-permeable, non-specific inhibitor of cAMP and cGMP phosphodiesterases (IC50 = 2-50 µM).
          Biological Information
          Primary TargetcAMP and cGMP phosphodiesterases
          Primary Target IC<sub>50</sub>2-50 µM against cAMP and cGMP phosphodiesterases
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableY
          Safety Information according to GHS
          RTECSZD8500000
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution in ethanol or methanol, refrigerate (4°C). Following reconstitution in DMSO, aliquot and freeze (-20°C). Ethanol/methanol and DMSO stock solutions are stable for up to 6 months at 4°C or -20°C, respectively.
          Global Trade Item Number
          Catalogue Number GTIN
          410957-1GM 04055977211139
          410957-250MG 04055977211146