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428025 α-Latrotoxin, Latrodectus tredecimguttatus - CAS 65988-34-3 - Calbiochem

Causes massive release of exocytotic neurotransmitter synaptic vesicles from a wide variety of central and peripheral synaptic junctions of vertebrates via Ca2+-dependent and -independent parallel mechanisms at concentrations as low as 100 pM.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: α-Ltx

428025
  
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      Overview

      Replacement Information

      Key Spec Table

      CAS #
      65988-34-3
      Description
      OverviewCauses massive release of exocytotic neurotransmitter synaptic vesicles from a wide variety of central and peripheral synaptic junctions of vertebrates via Ca2+-dependent and -independent parallel mechanisms at concentrations as low as 100 pM. Stimulates Ca2+-independent GABA and glutamate release from cortical astrocytes in culture.
      Catalogue Number428025
      Brand Family Calbiochem®
      Synonymsα-Ltx
      References
      ReferencesParpura, V., et al. 1995. FEBS Lett. 360, 266.
      Storchak, L.G., et al. 1994. FEBS Lett. 351, 267.
      Osipenko, O.N., et al. 1993. Toxicon 31, 1123.
      Valtorta, F., et al. 1988. J. Cell Biol. 107, 2717.
      Grasso, A. 1976. Biochem. Biophys. Acta 439, 406.
      Frontali, B., et al. 1976. J. Cell Biol. 68, 462.
      Product Information
      CAS number65988-34-3
      ATP CompetitiveN
      FormWhite lyophilized solid
      ReversibleN
      Applications
      Biological Information
      Biological activityEffective concentration: 100 pm-1 nm
      Primary TargetCauses release of exocytotic neurotransmitter synaptic vesicles from a wide variety of central and peripheral synaptic junctions of vertebrates
      PurityOne distinct band by SDS-PAGE
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSOE9020000
      Safety Information
      R PhraseR: 20/21/22

      Harmful by inhalation, in contact with skin and if swallowed.
      S PhraseS: 36

      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short term storage. Stock solutions are stable for up to 1 year at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      428025 0

      Documentation

      α-Latrotoxin, Latrodectus tredecimguttatus - CAS 65988-34-3 - Calbiochem MSDS

      Title

      Safety Data Sheet (SDS) 

      α-Latrotoxin, Latrodectus tredecimguttatus - CAS 65988-34-3 - Calbiochem Certificates of Analysis

      TitleLot Number
      428025

      References

      Reference overview
      Parpura, V., et al. 1995. FEBS Lett. 360, 266.
      Storchak, L.G., et al. 1994. FEBS Lett. 351, 267.
      Osipenko, O.N., et al. 1993. Toxicon 31, 1123.
      Valtorta, F., et al. 1988. J. Cell Biol. 107, 2717.
      Grasso, A. 1976. Biochem. Biophys. Acta 439, 406.
      Frontali, B., et al. 1976. J. Cell Biol. 68, 462.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision07-April-2008 RFH
      Synonymsα-Ltx
      DescriptionCauses massive release of exocytotic neurotransmitter synaptic vesicles from a wide variety of central and peripheral synaptic junctions of vertebrates via Ca2+-dependent and independent parallel mechanisms at concentrations as low as 100 pM. Stimulates Ca2+-independent GABA and glutamate release from cortical astrocytes in culture.
      FormWhite lyophilized solid
      CAS number65988-34-3
      RTECSOE9020000
      PurityOne distinct band by SDS-PAGE
      Biological activityEffective concentration: 100 pm-1 nm
      SolubilityDissolve in 0.5 ml cold H₂O with gentle stirring; add 0.5 ml glycerol yeilding a stock solution of 300 nm α-latrotoxin in 50% glycerol.
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short term storage. Stock solutions are stable for up to 1 year at -20°C.
      Toxicity Harmful
      ReferencesParpura, V., et al. 1995. FEBS Lett. 360, 266.
      Storchak, L.G., et al. 1994. FEBS Lett. 351, 267.
      Osipenko, O.N., et al. 1993. Toxicon 31, 1123.
      Valtorta, F., et al. 1988. J. Cell Biol. 107, 2717.
      Grasso, A. 1976. Biochem. Biophys. Acta 439, 406.
      Frontali, B., et al. 1976. J. Cell Biol. 68, 462.