368043
Granzyme B, Human, Recombinant, E. coli
Synonym(s):
GzmB
form
liquid
Application
Granzyme B, Human, Recombinant, E. coli, is a serine protease used by activated cytotoxic T cells to induce apoptosis. Induces cell perforation and initiates proteolysis leading to cell death.
General description
Recombinant, human granzyme B expressed in E. coli. Granzyme B (GzmB) is a serine protease that is involved in cytotoxic T lymphocyte-induced (CTL) cell death. It is reported to participate in the perforation of target cells and initiation of proteolysis that leads apoptosis. Similar to caspases, granzyme B preferentially cleaves substrate proteins with aspartic acid in the P1 position.
Recombinant, human granzyme B expressed in E. coli. Granzyme B (GzmB) is a serine protease that is used by activated cytotoxic T lymphocytes (CTL) to induce target cell apoptosis. It is involved in the perforation of target cells and initiation of proteolysis that leads the cell into the apoptosis pathway.
Other Notes
One unit is defined as the amount of enzyme that will hydrolyze 1 nmol Ac-IEPD-pNA per min 25° C, pH 8.0.
Physical form
In TBS, 50% glycerol.
Preparation Note
Following initial thaw, aliquot and freeze (-70°C).
signalword
Danger
hcodes
pcodes
Hazard Classifications
Resp. Sens. 1
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
E Wilharm et al.
The Journal of biological chemistry, 274(38), 27331-27337 (1999-09-10)
Granzymes are granule-stored lymphocyte serine proteases that are implicated in T- and natural killer cell-mediated cytotoxic defense reactions after target cell recognition. A fifth human granzyme (granzyme 3, lymphocyte tryptase-2), renamed as granzyme K (gene name GZMK), has recently been
J L Harris et al.
The Journal of biological chemistry, 273(42), 27364-27373 (1998-10-09)
Granzyme B is a protease involved in the induction of rapid target cell death by cytotoxic lymphocytes. Definition of the substrate specificity of granzyme B allows for the identification of in vivo substrates in this process. By using the combinatorial
Related Content
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service