196872
BAY 11-7085 - CAS 196309-76-9 - Calbiochem
Synonym(s):
(E)3-[(4-t-Butylphenyl)sulfonyl]-2-propenenitrile
Biochem/physiol Actions
- TNF-α-inducible phosphorylation of I?Bα
- Target IC<SUB>50</SUB>:10 μM against TNF-α-inducible phosphorylation of I?Bα
General description
Exhibits biological properties similar to that of BAY 11-7082 (Cat. No. 196870). BAY 11-7085 has also been shown to have potent anti-inflammatory properties in vivo.
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Storage Class
10-13 - German Storage Class 10 to 13
Certificates of Analysis (COA)
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H Ni et al.
British journal of haematology, 115(2), 279-286 (2001-11-13)
Nuclear factor-kappa B (NF-kappa B) is an important transcription factor that regulates survival in many cells. Activated NF-kappa B has been shown to protect some haematopoietic neoplastic cells from apoptosis. In the present study, we analysed NF-kappa B status in
J W Pierce et al.
The Journal of biological chemistry, 272(34), 21096-21103 (1997-08-22)
We have identified two compounds that inhibit the expression of endothelial-leukocyte adhesion molecules intercellular adhesion molecule-1, vascular cell adhesion molecule-1, and E-selectin. These compounds act by inhibiting tumor necrosis factor-alpha-induced phosphorylation of IkappaB-alpha, resulting in decreased nuclear factor-kappaB and decreased
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