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48-602MAG
Buffer Detection Kit for Magnetic Beads
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14-540M
Sigma-AldrichTie2 Protein, active, 250 µg
Active, N-terminal His6-tagged recombinant human Tie2 residues 771-end, for use in Kinase Assays.
More>>Active, N-terminal His6-tagged recombinant human Tie2 residues 771-end, for use in Kinase Assays. Less<<
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Overview
Replacement Information
Description
Catalogue Number
14-540M
Brand Family
Upstate
Trade Name
Upstate
Description
Tie2 Protein, active, 250 µg
Overview
N-terminal His6-tagged recombinant human Tie2 residues 771-end
The TEK receptor tyrosine kinase is expressed almost exclusively in endothelial cells in mice, rats, and humans. This receptor possesses a unique extracellular domain containing 2 immunoglobulin-like loops separated by 3 epidermal growth factor-like repeats that are connected to 3 fibronectin type III-like repeats. The ligand for the receptor is angiopoietin-1. Defects in TEK are associated with inherited venous malformations; the TEK signaling pathway appears to be critical for endothelial cell-smooth muscle cell communication in venous morphogenesis. TEK is closely related to the TIE receptor tyrosine kinase.
FUNCTION: SwissProt: Q02763 # This protein is a protein tyrosine-kinase transmembrane receptor for angiopoietin 1. It may constitute the earliest mammalian endothelial cell lineage marker. Probably regulates endothelial cell proliferation, differentiation and guides the proper patterning of endothelial cells during blood vessel formation. SIZE: 1124 amino acids; 125811 Da SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. TISSUE SPECIFICITY: Predominantly expressed in endothelial cells and their progenitors, the angioblasts. Has been directly found in placenta and lung, with a lower level in umbilical vein endothelial cells, brain and kidney. DISEASE:SwissProt: Q02763 # Defects in TEK are a cause of dominantly inherited venous malformations (VMCM) [MIM:600195]; an error of vascular morphogenesis characterized by dilated, serpiginous channels. SIMILARITY: SwissProt: Q02763 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. Tie subfamily. & Contains 3 EGF-like domains. & Contains 3 fibronectin type-III domains. & Contains 2 Ig-like C2-type (immunoglobulin-like) domains. & Contains 1 protein kinase domain.
Molecular Weight
42kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance
routinely evaluated by phosphorylation of Poly (Glu4-Tyr) (4:1)
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions
6 months at -70C
Packaging Information
Material Size
250 µg
Material Package
Also available in 10 μg size (cat#14-540) and in bulk (cat# 14-540-K).
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number
GTIN
14-540M
04053252331565
Documentation
Related Products & Applications
Product Families
Kinase & Phosphatase Products
Millipore offers a large portfolio of Kinases, Phophatases, Substrates, Inhibitors, Kits, reagents & tools for Signaling research. See below for a list of these products, in multiple pack sizes. Learn More >>
