654270 Sigma-AldrichTNP-470 - CAS 129298-91-5 - Calbiochem
TNP-470, CAS 129298-91-5, is a cell-permeable Fumagillin (Cat. No. 344845) analog that specifically inhibits MetAP2 methionine aminopeptidase activity (IC50 = 1 nM for human MetAP2).
More>> TNP-470, CAS 129298-91-5, is a cell-permeable Fumagillin (Cat. No. 344845) analog that specifically inhibits MetAP2 methionine aminopeptidase activity (IC50 = 1 nM for human MetAP2). Less<<TNP-470 - CAS 129298-91-5 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: AGM-1470, O-(Chloroacetyl-carbamoyl)fumagillol, AGM1470, MetAP-2 Inhibitor II, MetAP2 Inhibitor II, Methionine Aminopeptidase 2 Inhibitor II, TNP470
Recommended Products
Overview
| Replacement Information |
|---|
Key Spec Table
| CAS # | Empirical Formula |
|---|---|
| 129298-91-5 | C₁₉H₂₈CINO₆ |
Pricing & Availability
| Catalogue Number | Availability | Packaging | Qty/Pack | Price | Quantity | |
|---|---|---|---|---|---|---|
| 654270-10MG |
|
Glass bottle | 10 mg |
|
— |
| Description | |
|---|---|
| Overview | A cell-permeable Fumagillin (Cat. No. 344845) analog that inhibits MetAP2, but not MetAP1, methionine aminopeptidase activity (IC50 = 1 nM against human MetAP2), without affecting the inhibitory activity of MetAP2 against HRI- (heme-regulated inhibitor kinase) catalyzed eIF-2α phosphorylation. A potent endothelial cytostasis inducer (IC50 = 25 pM and 37 pM, respectively, against HUVEC and bovine BAEC) in vitro and an effective anti-angiogenesis agent in vivo (2 to 100 mg/kg in mice and rats; s.c.). |
| Catalogue Number | 654270 |
| Brand Family | Calbiochem® |
| Synonyms | AGM-1470, O-(Chloroacetyl-carbamoyl)fumagillol, AGM1470, MetAP-2 Inhibitor II, MetAP2 Inhibitor II, Methionine Aminopeptidase 2 Inhibitor II, TNP470 |
| Product Information | |
|---|---|
| CAS number | 129298-91-5 |
| Form | White to light yellow solid |
| Hill Formula | C₁₉H₂₈CINO₆ |
| Chemical formula | C₁₉H₂₈CINO₆ |
| Structure formula Image | |
| Quality Level | MQ200 |
| Biological Information | |
|---|---|
| Purity | ≥97% by HPLC |
| Physicochemical Information |
|---|
| Dimensions |
|---|
| Materials Information |
|---|
| Toxicological Information |
|---|
| Safety Information according to GHS |
|---|
| Safety Information | |
|---|---|
| R Phrase | R: 36/37/38 Irritating to eyes, respiratory system and skin. |
| Product Usage Statements |
|---|
| Packaging Information |
|---|
| Transport Information |
|---|
| Supplemental Information |
|---|
| Specifications |
|---|
| Global Trade Item Number | |
|---|---|
| Catalogue Number | GTIN |
| 654270-10MG | 04055977184655 |
Documentation
TNP-470 - CAS 129298-91-5 - Calbiochem MSDS
| Title |
|---|
TNP-470 - CAS 129298-91-5 - Calbiochem Certificates of Analysis
| Title | Lot Number |
|---|---|
| 654270 |
References
| Reference overview |
|---|
| Zhang, Y., et al. 2000. Proc. Natl. Acad. Sci. USA 97, 6427. Sin, N., et al. Proc. Natl. Acad. Sci. USA 94, 6099. Yamaoka, M., et al. 1993. Cancer Res. 53, 4262. Kusaka, M., et al. 1991. Biochem. Biophys. Res. Commun. 174, 1070. Ingber, D., et al. 1990. Nature 348, 555. |
| Data Sheet | ||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
|