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616452 TGF-β RI Kinase Inhibitor II - CAS 446859-33-2 - Calbiochem

TGF-β RI Kinase Inhibitor II, CAS 446859-33-2, is a cell-permeable, potent, reversible, ATP-competitive inhibitor of TGF-β R1 kinase (IC₅₀ = 23 nM and 4 nM for ALK5 binding & auto-phosphorylation)

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TGF-β RI Kinase Inhibitor II - CAS 446859-33-2 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: ALK5 Inhibitor II, Transforming Growth Factor-β Type I Receptor Kinase Inhibitor II, 2-(3-(6-Methylpyridin-2-yl)-1H-pyrazol-4-yl)-1,5-naphthyridine

Primary Target: ALKS binding
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616452
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Overview

Key Spec Table

CAS #Empirical Formula
446859-33-2C₁₇H₁₃N₅

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      Description
      OverviewA cell-permeable naphthyridinyl pyrazolo compound that acts as a potent, selective, reversible, and ATP-competitive inhibitor of TGF-β type I receptor (ALK5; IC50 = 23 nM, 4 nM and 18 nM for ALK5 binding, ALK5 auto-phosphorylation and TGF-β cellular assay in HepG2 cells, respectively). Minimally affects a panel of 9 closely related kinases including p38 MAPK at IC50 > 16 µM. Also available as a 50 mM solution in DMSO (Cat. No. 508158).
      Catalogue Number616452
      Brand Family Calbiochem®
      SynonymsALK5 Inhibitor II, Transforming Growth Factor-β Type I Receptor Kinase Inhibitor II, 2-(3-(6-Methylpyridin-2-yl)-1H-pyrazol-4-yl)-1,5-naphthyridine
      References
      ReferencesGellibert, F., et al. 2004. J. Med. Chem. 47, 4494.
      Ichida, J. K., et al. 2009. 5, 491.
      Product Information
      CAS number446859-33-2
      ATP CompetitiveY
      FormYellow solid
      Hill FormulaC₁₇H₁₃N₅
      Chemical formulaC₁₇H₁₃N₅
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Primary TargetALKS binding
      Primary Target IC<sub>50</sub>23 nM
      Secondary targetALK 5 auto phosphorylation (IC₅₀ = 4 nM)
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Catalogue Number GTIN
      616452-2MG 04055977185829