572630 Sigma-AldrichSU5402 - CAS 215543-92-3 - Calbiochem
SU5402, CAS 215543-92-3, is a cell-permeable, reversible, and ATP-competitive inhibitor of the tyrosine kinase activity of FGFR1 (IC₅₀ = 10-20 µM in the presence of 1 mM ATP).
More>> SU5402, CAS 215543-92-3, is a cell-permeable, reversible, and ATP-competitive inhibitor of the tyrosine kinase activity of FGFR1 (IC₅₀ = 10-20 µM in the presence of 1 mM ATP). Less<<SU5402 - CAS 215543-92-3 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: 3-[3-(2-Carboxyethyl)-4-methylpyrrol-2-methylidenyl]-2-indolinone
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Overview
Key Spec Table
| CAS # | Empirical Formula |
|---|---|
| 215543-92-3 | C₁₇H₁₆N₂O₃ |
Pricing & Availability
| Catalogue Number | Availability | Packaging | Qty/Pack | Price | Quantity | |
|---|---|---|---|---|---|---|
| 572630-1MG |
|
Plastic ampoule | 1 mg |
|
— | |
| 572630-2MG |
|
Glass bottle | 2 mg |
|
— | |
| 572630-500UG |
|
Plastic ampoule | 500 μg |
|
— |
| Description | |
|---|---|
| Overview | A cell-permeable, reversible, and ATP-competitive inhibitor of the tyrosine kinase activity of fibroblast growth factor receptor 1 (FGFR1; IC50 = 10-20 µM in the presence of 1 mM ATP). Also inhibits aFGF-induced tyrosine phosphorylation of ERK1 and ERK2 (IC50 = 10-20 µM). In contrast to SU4984 (Cat. No. 572625), SU5402 is only a weak inhibitor of tyrosine phosphorylation of the PDGF receptor and does not inhibit phosphorylation of the insulin receptor. Does not inhibit the kinase activity of the EGF receptor. A 10 mM (500 µg/169 µl) solution of SU5402 (Cat. No. 572631) in DMSO is also available. |
| Catalogue Number | 572630 |
| Brand Family | Calbiochem® |
| Synonyms | 3-[3-(2-Carboxyethyl)-4-methylpyrrol-2-methylidenyl]-2-indolinone |
| References | |
|---|---|
| References | Mohammadi, M., et al. 1997. Science 276, 955. |
| Product Information | |
|---|---|
| CAS number | 215543-92-3 |
| ATP Competitive | Y |
| Declaration | Not available for sale in the United States. |
| Form | Lyophilized solid |
| Hill Formula | C₁₇H₁₆N₂O₃ |
| Chemical formula | C₁₇H₁₆N₂O₃ |
| Reversible | Y |
| Structure formula Image | |
| Quality Level | MQ200 |
| Physicochemical Information | |
|---|---|
| Cell permeable | Y |
| Global Trade Item Number | |
|---|---|
| Catalogue Number | GTIN |
| 572630-1MG | 04055977266207 |
| 572630-2MG | 04055977266238 |
| 572630-500UG | 04055977266269 |