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566331 SIRT2 Inhibitor II, AK-1 - CAS 330461-64-8 - Calbiochem

The SIRT2 Inhibitor II, AK-1, also referenced under CAS 330461-64-8, controls the biological activity of SIRT2. This small molecule/inhibitor is primarily used for Cell Structure applications.

SIRT2 Inhibitor II, AK-1 - CAS 330461-64-8 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 3-(azepan-1-ylsulfonyl)-N-(3-nitrophenyl)benzamide, SIRT2 Inhibitor II, AK-1

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566331
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Overview

Key Spec Table

CAS #Empirical Formula
330461-64-8C₁₉H₂₁N₃O₅S

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      Description
      OverviewA cell permeable, benzylsulfonamide that inhibits SIRT2 activity (IC50= 12.5 µM through enzymatic assay) by targeting the SIRT2 nicotinamide binding site, but may also target SIRT1 and SIRT3 (IC50 >40 µM) with much less potency. Western analysis illustrates that treatment with AK-1 (> 25 µM) leads to an increase in acetylated tubulin. AK-1 (1 to 10 µM) is shown to rescue neuronal dysfunction in two in vivo models of Huntington's Disease (HD) in Dropshila and Caenorhabditis elegans. It also demonstrates recovery of neuronal toxicity in a primary model of HD from 1µM to 4 µM similar to that of genetic SIRT2 inhibition, and also correlates with the negative regulation of sterol biosynthesis.
      Catalogue Number566331
      Brand Family Calbiochem®
      Synonyms3-(azepan-1-ylsulfonyl)-N-(3-nitrophenyl)benzamide, SIRT2 Inhibitor II, AK-1
      References
      ReferencesLuthi-Carter, R., et al. 2010. Proc. Natl. Acad. Sci. 107, 7927.
      Outeiro, TF., et al. 2007. Science 317, 516.
      Product Information
      CAS number330461-64-8
      FormOff-white solid
      Hill FormulaC₁₉H₂₁N₃O₅S
      Chemical formulaC₁₉H₂₁N₃O₅S
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Purity>95% by HPLC
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Global Trade Item Number
      Catalogue Number GTIN
      566331-10MG 04055977191479