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528240 Platelet Membrane Glycoproteins, IIbIIIa, Human Platelets

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528240
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528240-1MG
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      Description
      OverviewNative, platelet membrane glycoprotein IIbIIIaA from human platelets. A platelet integrin that binds to fibrinogen via the recognition sequence Arg-Gly-Asp-Ser. Acts as a receptor for such adhesive ligands as fibrinogen, fibronectin and von Willebrand factor during platelet stimulation. Glycoproteins IIb and IIIa constitute the fibrinogen receptor and are required for platelet aggregation. Glycoprotein IIb consists of two disulfide-linked subunits, GPIIbα and GPIIbβ, whereas GPIIIa has only one polypeptide chain.
      Catalogue Number528240
      Brand Family Calbiochem®
      SynonymsGPIIbIIIa, Fibrinogen Receptor, CD41/CD61
      References
      ReferencesSchwarz M., et al. 2004. J. Pharmacol. Exp. Therap. 308, 1002.
      Wippler, J., et al. 1994. J. Biol. Chem. 269, 8754.
      Product Information
      FormLiquid
      FormulationIn 100 mM NaCl, 20 mM Tris-HCl, 1 mM CaCl₂, 50% glycerol, ≤0.1% sodium azide, pH 7.4.
      Quality LevelMQ100
      Biological Information
      SourcePrepared from serum that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
      Concentration Label Please refer to vial label for lot-specific concentration
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Standard Handling
      Storage ≤ -70°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C). Avoid freeze/thaw cycles.
      Global Trade Item Number
      Catalogue Number GTIN
      528240-1MG 04055977196535