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530618 Pin1 Inhibitor, DTM - CAS 725-32-6 - Calbiochem

A cell permeable competitive inhibitor of Pin1 (EC₅₀ = 4.1 µM, Ki = 50 nM).

Pin1 Inhibitor, DTM - CAS 725-32-6 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: PPIase-Parvulin Inhibitor II

Primary Target: Pin1
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530618
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Overview

Key Spec Table

CAS #Empirical Formula
725-32-6C₁₂H₂₀N₂S₃

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      		 Glass bottle 10 mg
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      Description
      OverviewA cell permeable thiuram monosulfide based compound that acts as a competitive inhibitor of Pin1 (EC50 = 4.1 µM, Ki = 50 nM). Binds to the active site of the PPIase domain of Pin1 hydrophobically and blocks the active pocket. Shown to specifically inhibit peptidyl-prolyl cis/trans isomerase activity in HeLa cells. Inhibits the proliferation of HCT116 cells (EC50 = 10 µM) by arresting cell cycle at the G0 phase. Also shown to reduce the endogenous Runx2 protein levels in the MC3T3-E1 cells. Displays excellent solubility in DMSO (~100 mM).

      Please note that the molecular weight for this compound is batch-specific due to variable water content.
      Catalogue Number530618
      Brand Family Calbiochem®
      SynonymsPPIase-Parvulin Inhibitor II
      References
      ReferencesYoon, W-J., et al. 2013. J. Cell Physiol. 228, 2377.
      Tatara, Y., et al. 2009.Biochem Biophys Res Commun. 384, 394.
      Product Information
      CAS number725-32-6
      FormYellow powder
      Hill FormulaC₁₂H₂₀N₂S₃
      Chemical formulaC₁₂H₂₀N₂S₃
      ReversibleY
      Quality LevelMQ100
      Biological Information
      Primary TargetPin1
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Catalogue Number GTIN
      5.30618.0001 04055977260984