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524390 Phorbol-12,13-dibutyrate - CAS 37558-16-0 - Calbiochem

Strong irritant for mouse skin, but only moderately active as a tumor promoter.

Phorbol-12,13-dibutyrate - CAS 37558-16-0 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: PDBu, PKC Activator II

Primary Target: Na+,K+- ATPase
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524390
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
37558-16-0C₂₈H₄₀O₈

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524390-1MG
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      524390-5MG
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          Description
          OverviewStrong irritant for mouse skin, but only moderately active as a tumor promoter. Activates protein kinase C. Stimulates the phosphorylation of Na+,K+- ATPase, thereby inhibiting its activity. Promotes the expression of inducible NOS in cultured hepatocytes. Commonly used in binding studies or in applications requiring high concentrations of phorbol compounds.
          Catalogue Number524390
          Brand Family Calbiochem®
          SynonymsPDBu, PKC Activator II
          References
          ReferencesFisone, G., et al. 1995. J. Biol. Chem. 270, 2427.
          Lee, E.J., et al. 1994. Brain Res. 665, 127.
          Critz, S.D., et al. 1993. J. Neurochem. 60, 1175.
          Iredale, P.A., et al. 1993. Biochem. Pharmacol. 45, 611.
          Critz, S.D., and Byrne J.H. 1992. J. Neurophys. 68, 1079.
          Hortelano, S., et al. 1992. J. Biol. Chem. 267, 24937.
          Ward C.A., and Moffat, M.P. 1992. J. Mol. Cell. Cardiol. 24, 937.
          Product Information
          CAS number37558-16-0
          ATP CompetitiveN
          FormClear film or white crystalline solid
          Hill FormulaC₂₈H₄₀O₈
          Chemical formulaC₂₈H₄₀O₈
          ReversibleN
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          Biological Information
          Primary TargetNa+,K+- ATPase
          Purity≥99% by HPLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSEK7767000
          Safety Information
          R PhraseR: 26/27/28-36/37/38-40-41

          Very toxic by inhalation, in contact with skin and if swallowed.
          Irritating to eyes, respiratory system and skin.
          Limited evidence of a carcinogenic effect.
          Risk of serious damage to eyes.
          S PhraseS: 26-36/37/39-45

          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          Wear suitable protective clothing, gloves and eye/face protection.
          In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Highly Toxic & Carcinogenic / Teratogenic
          Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
          Storage -20°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 6 months at -20°C. With frequent use, the DMSO stock solutions may accumulate water. The presence of water in the stock solution will accelerate the decomposition of the product, resulting in significant loss of activity in 2-3 months.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications
          Global Trade Item Number
          Catalogue Number GTIN
          524390-1MG 04055977271546
          524390-5MG 04055977271553

          Documentation

          Phorbol-12,13-dibutyrate - CAS 37558-16-0 - Calbiochem MSDS

          Title

          Safety Data Sheet (SDS) 

          Phorbol-12,13-dibutyrate - CAS 37558-16-0 - Calbiochem Certificates of Analysis

          TitleLot Number
          524390

          References

          Reference overview
          Fisone, G., et al. 1995. J. Biol. Chem. 270, 2427.
          Lee, E.J., et al. 1994. Brain Res. 665, 127.
          Critz, S.D., et al. 1993. J. Neurochem. 60, 1175.
          Iredale, P.A., et al. 1993. Biochem. Pharmacol. 45, 611.
          Critz, S.D., and Byrne J.H. 1992. J. Neurophys. 68, 1079.
          Hortelano, S., et al. 1992. J. Biol. Chem. 267, 24937.
          Ward C.A., and Moffat, M.P. 1992. J. Mol. Cell. Cardiol. 24, 937.

          Brochure

          Title
          Caspases and other Apoptosis Related Tools Brochure
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision19-August-2008 RFH
          SynonymsPDBu, PKC Activator II
          DescriptionStrong irritant for mouse skin, but only moderately active as a tumor promoter. Activates protein kinase C (PKC). Stimulates the phosphorylation of Na+-K+ ATPase, thereby inhibiting its activity. Promotes the expression of iNOS in cultured hepatocytes. PDBu can be diluted to 30 µM in aqueous solutions, so it is commonly used in binding studies or in applications requiring high concentrations. It is easier to remove PDBu than PMA from cells in culture.
          FormClear film or white crystalline solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number37558-16-0
          RTECSEK7767000
          Chemical formulaC₂₈H₄₀O₈
          Structure formulaStructure formula
          Purity≥99% by HPLC
          SolubilityDMSO (10 mg/ml). Further dilute with aqueous buffers just prior to use.
          Storage -20°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 6 months at -20°C. With frequent use, the DMSO stock solutions may accumulate water. The presence of water in the stock solution will accelerate the decomposition of the product, resulting in significant loss of activity in 2-3 months.
          Toxicity Highly Toxic & Carcinogenic / Teratogenic
          ReferencesFisone, G., et al. 1995. J. Biol. Chem. 270, 2427.
          Lee, E.J., et al. 1994. Brain Res. 665, 127.
          Critz, S.D., et al. 1993. J. Neurochem. 60, 1175.
          Iredale, P.A., et al. 1993. Biochem. Pharmacol. 45, 611.
          Critz, S.D., and Byrne J.H. 1992. J. Neurophys. 68, 1079.
          Hortelano, S., et al. 1992. J. Biol. Chem. 267, 24937.
          Ward C.A., and Moffat, M.P. 1992. J. Mol. Cell. Cardiol. 24, 937.