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531294 Perk Inhibitor III, LDN-0070977 - Calbiochem

A cell-permeable, reversible, and non ATP-competitive inhibitor of PERK (PKR-like ER kinase, IC₅₀ = 7.04 µM) and blocks PERK-dependent phosphorylation of elF2a.

Perk Inhibitor III, LDN-0070977 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: PKR-like ER kinase Inhibitor, LDN-0070977, LDN0070977, LDN 0070977

Primary Target: PERK
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      Overview

      Key Spec Table

      Empirical Formula
      C₁₂H₈N₂O
      Description
      Overview

      This product has been discontinued.



      A cell-permeable tricyclic heterocycle oxime that acts as a reversible and non ATP-competitive inhibitor of PERK (PKR-like ER kinase, IC50 = 7.04 µM) and blocks PERK-dependent phosphorylation of elF2a. Shown to reduce thapsigargin-induced elF2a phosphorylation in mouse embryonic fibroblasts over a wide range. Does not exhibit any cellular toxicity up to 50 µM levels.

      Please note that the molecular weight for this compound is batch-specific due to variable water content.

      Catalogue Number531294
      Brand Family Calbiochem®
      SynonymsPKR-like ER kinase Inhibitor, LDN-0070977, LDN0070977, LDN 0070977
      References
      ReferencesPytel, D., et al. 2014. J. Biomol. Screen. 19, 1024.
      Product Information
      FormOff-white powder
      Hill FormulaC₁₂H₈N₂O
      Chemical formulaC₁₂H₈N₂O
      ReversibleY
      Quality LevelMQ100
      Biological Information
      Primary TargetPERK
      Primary Target IC<sub>50</sub>7µ
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Catalogue Number GTIN
      531294 0