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Merck

526522

PIM1 Kinase Inhibitor IV

The PIM1 Kinase Inhibitor IV, also referenced under CAS 477845-12-8, controls the biological activity of PIM1. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Synonym(s):

PIM1 Kinase Inhibitor IV, 4-(3-(4-Chlorophenyl)-2,1-benzisoxazol-5-yl)-2-pyrimidinamine

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About This Item

Empirical Formula (Hill Notation):
C17H11ClN4O
CAS Number:
477845-12-8
Molecular Weight:
322.75
UNSPSC Code:
12352200

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Product Name

PIM1 Kinase Inhibitor IV, The PIM1 Kinase Inhibitor IV, also referenced under CAS 477845-12-8, controls the biological activity of PIM1. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

assay

≥97% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

yellow

solubility

DMSO: 5 mg/mL

shipped in

ambient

storage temp.

2-8°C

Quality Level

100

Disclaimer

Toxicity: Standard Handling (A)

General description

A pyrimidinyl-benzisoxazolo compound that interacts with Lys67 and Glu121 at the PIM1 active site and inhibits PIM1 kinase activity with a Ki value of 0.091 µM.

Other Notes

Pierce, A.C., et al. 2008. J. Med. Chem.51, 1972.

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

10-13 - German Storage Class 10 to 13

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Albert C Pierce et al.
Journal of medicinal chemistry, 51(6), 1972-1975 (2008-02-23)
To supplement the hits from a high throughput screen, docking was performed against Pim-1 kinase. Glide docking was augmented with a filter to require traditional or aromatic CH..O hydrogen bonds to the kinase hinge. Four diverse actives, of 96 molecules

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