Our broad portfolio consists of multiplex panels that allow you to choose, within the panel, analytes that best meet your needs. On a separate tab you can choose the premixed cytokine format or a single plex kit.
Cell Signaling Kits & MAPmates™
Choose fixed kits that allow you to explore entire pathways or processes. Or design your own kits by choosing single plex MAPmates™, following the provided guidelines.
The following MAPmates™ should not be plexed together:
-MAPmates™ that require a different assay buffer
-Phospho-specific and total MAPmate™ pairs, e.g. total GSK3β and GSK3β (Ser 9)
-PanTyr and site-specific MAPmates™, e.g. Phospho-EGF Receptor and phospho-STAT1 (Tyr701)
-More than 1 phospho-MAPmate™ for a single target (Akt, STAT3)
-GAPDH and β-Tubulin cannot be plexed with kits or MAPmates™ containing panTyr
.
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To begin designing your MILLIPLEX® MAP kit select a species, a panel type or kit of interest.
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48-602MAG
Buffer Detection Kit for Magnetic Beads
1 Kit
Space Saver Option Customers purchasing multiple kits may choose to save storage space by eliminating the kit packaging and receiving their multiplex assay components in plastic bags for more compact storage.
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Complex of N-terminal 6His-tagged recombinant murine p110α full length, containing the mutation E542K & untagged, recombinant, murine p85α full length.
More>>Complex of N-terminal 6His-tagged recombinant murine p110α full length, containing the mutation E542K & untagged, recombinant, murine p85α full length. Less<<
PI 3-Kinase (p110α(E542K)/p85α) murine, 10 µg MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Complex of N-terminal 6His-tagged recombinant murine p110α full length, containing the mutation E542K, and untagged, recombinant, murine p85α full length.
Background Information
The E542K substitution is a somatic mutation in p110α that has been associated with tumours of the colon and brain. Combined in vitro and in vivo studies have shown that this mutation confers higher lipid kinase activity than wild type, and is able to induce oncogenic transformation. (Kang S. et al., PNAS, (2005);102: 802-807 and Zhao J.J. et al., PNAS, (2005);102:18443-18448).
References
Product Information
Presentation
50 mM Tris/HCl pH7.5, 300 mM NaCl, 0.1 mM EGTA, 0.03% Brij-35, 270 mM sucrose, 0.2 mM PMSF, 1 mM benzamidine, 0.1% 2-mercaptoethanol. Frozen solution.
Complex of N-terminal 6His-tagged recombinant murine p110α full length, containing the mutation E542K & untagged, recombinant, murine p85α full length.
Biological Information
Source
Co-expressed by baculovirus in Sf21 insect cells.
Specific Activity
For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions
Store at -70°C from date of shipment. For maximum recovery of product, centrifuge original vial prior to removing the cap.
Packaging Information
Material Size
10 µg
Material Package
Also available in 250μg size --call for pricing and availability and reference catalog number 14-791M when ordering the 250μg size.
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number
GTIN
14-791
04053252679087
Documentation
PI 3-Kinase (p110α(E542K)/p85α) murine, 10 µg Certificates of Analysis
Millipore offers a large portfolio of Kinases, Phophatases, Substrates, Inhibitors, Kits, reagents & tools for Signaling research. See below for a list of these products, in multiple pack sizes. Learn More >>
