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475911 Myeloperoxidase, Human Polymorphonuclear Leukocytes

A lysosomal enzyme that catalyzes oxidations by hydrogen peroxide, including MPO-chloride-mediated killing of microbes and tumor cells, inactivation of chemotactic factors, and cross-linking of protei

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Myeloperoxidase, Human Polymorphonuclear Leukocytes MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: MPO

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475911
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      Description
      OverviewNative, human myeloperoxidase from polymorphonuclear leukocytes. A lysosomal enzyme that catalyzes oxidations by hydrogen peroxide, including MPO-chloride-mediated killing of microbes and tumor cells, inactivation of chemotactic factors, and cross-linking of proteins. MPO catalyzes the formation of hypochlorous acid that kills bacteria either by binding the halide ion to intracellular constituents or by oxidation of bacterial lipids and proteins.
      Catalogue Number475911
      Brand Family Calbiochem®
      SynonymsMPO
      References
      ReferencesNauseef, W.M., et al. 1998. J. Leukocyte Biol. 63, 264.
      Panasenko, O.M., et al. 1994. Free Radic. Biol. Med. 16, 143.
      Mulligan, M.S., et al. 1992. Br. J. Pharmacol. 107, 1159.
      Sharonov, B.P., and Churilova, I.V. 1992. Biochem. Biophys. Res. Commun. 189, 1129.
      Product Information
      CAS number9003-99-0
      Unit of DefinitionOne unit is defined as the amount of enzyme that will reduce 1.0 µmol H₂O₂ per min at 25°C, pH 6.0.
      EC number1.11.1.7
      FormLyophilized
      FormulationLyophilized from 100-700 mM NaCl, 50 mM sodium acetate buffer, pH 6.0.
      Quality LevelMQ200
      Biological Information
      Purity≥95% by SDS-PAGE
      SourcePrepared from blood that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
      Specific Activity150-200 units/mg protein
      Storage and Shipping Information
      Ship Code Blue Ice Only
      Toxicity Standard Handling
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C or -70°C). Stock solutions are stable for up to 1 year at -20°C or -70°C.
      Global Trade Item Number
      Catalogue Number GTIN
      475911-100UG 04055977203103