444939 Sigma-AldrichMEK Inhibitor VII - CAS 305350-87-2 - Calbiochem
The MEK1/2 Inhibitor, also referenced under CAS 305350-87-2, controls the biological activity of MEK1/2. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation app
More>> The MEK1/2 Inhibitor, also referenced under CAS 305350-87-2, controls the biological activity of MEK1/2. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Less<<Synonyms: SL327, Z-& E-α-(Amino-((4-aminophenyl)thio)methylene)-2-(trifluoromethyl)benzeneacetonitrile
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Overview
Key Spec Table
CAS # | Empirical Formula |
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305350-87-2 | C₁₆H₁₂F₃N₃S |
Description | |
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Overview | A cell-permeable vinylogous cyanamide that acts as a selective inhibitor of MEK1/2 (IC50 = 180 nM and 220 nM, respectively). Shown to inhibit AP-1 activity (IC50 = 2.03 µM). Inhibits ERK1, MKK3/p38, MKK4, JNK, and PKC activities at higher concentrations (IC50 > 10 µM). Reported to offer neuroprotection against ischemic brain injury in mice by selectively blocking ERK1/2 activation. Also suppresses IL-1β expression. Displays enhanced aqueous solubility compared to U0126 (Cat. No. 662005). Uncompetitive with respect to ATP. |
Supplied as a mixture of Z- and E-isomers. | |
Catalogue Number | 444939 |
Brand Family | Calbiochem® |
Synonyms | SL327, Z-& E-α-(Amino-((4-aminophenyl)thio)methylene)-2-(trifluoromethyl)benzeneacetonitrile |
Product Information | |
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CAS number | 305350-87-2 |
ATP Competitive | N |
Form | Off-white solid |
Hill Formula | C₁₆H₁₂F₃N₃S |
Chemical formula | C₁₆H₁₂F₃N₃S |
Reversible | N |
Structure formula Image | |
Quality Level | MQ100 |
Biological Information | |
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Primary Target | MEK 1, MEK 2 |
Primary Target IC<sub>50</sub> | 180 nM and 220 nM against MEK1 and MEK2, respectively |
Purity | ≥97% by HPLC |
Physicochemical Information | |
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Cell permeable | Y |
Packaging Information | |
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Packaged under inert gas | Packaged under inert gas |
Global Trade Item Number | |
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Catalogue Number | GTIN |
444939 | 0 |