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440208 LY 231617

A potent antioxidant that readily crosses the blood-brain barrier.

LY 231617 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 2,6-bis(1,1-Dimethylethyl)-4-[[(1-ethyl)amino]methyl]phenol, HCl

440208
  
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      Overview

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      141545-89-3C₁₇H₂₉NO · HCl
      Description
      Overview

      This product has been discontinued.





      A potent antioxidant that readily crosses the blood-brain barrier. Significantly reduces ischemia-induced or hydrogen peroxide-induced neuronal damage and inhibits lipid peroxidation (IC50 = 22 µM). Prevents nuclear translocation of activated NF-κB in hippocampal neurons.
      Catalogue Number440208
      Brand Family Calbiochem®
      Synonyms2,6-bis(1,1-Dimethylethyl)-4-[[(1-ethyl)amino]methyl]phenol, HCl
      References
      ReferencesToung, T.J., et al. 2000. Crit. Care Med. 28, 196.
      Fuson, K.S., et al. 1999. J. Neurochem. 72, 1154.
      Clemens, J.A., et al. 1998. Stroke 29, 677.
      Callaway, J.K., et al. 1998. J. Pharmacol. Toxicol. Methods 39, 155.
      O’Neill, M.J., et al. 1997. Brain Res. 760, 170.
      Clemens, J.A., et al. 1993. Stroke 24, 716.
      Product Information
      CAS number141545-89-3
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₁₇H₂₉NO · HCl
      Chemical formulaC₁₇H₂₉NO · HCl
      ReversibleN
      Structure formula ImageStructure formula Image
      Applications
      Biological Information
      Primary Targetinhibits lipid peroxidation
      Primary Target IC<sub>50</sub>22 µM against lipid peroxidation
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      440208 0

      Documentation

      LY 231617 MSDS

      Title

      Safety Data Sheet (SDS) 

      LY 231617 Certificates of Analysis

      TitleLot Number
      440208

      References

      Reference overview
      Toung, T.J., et al. 2000. Crit. Care Med. 28, 196.
      Fuson, K.S., et al. 1999. J. Neurochem. 72, 1154.
      Clemens, J.A., et al. 1998. Stroke 29, 677.
      Callaway, J.K., et al. 1998. J. Pharmacol. Toxicol. Methods 39, 155.
      O’Neill, M.J., et al. 1997. Brain Res. 760, 170.
      Clemens, J.A., et al. 1993. Stroke 24, 716.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision07-April-2008 RFH
      Synonyms2,6-bis(1,1-Dimethylethyl)-4-[[(1-ethyl)amino]methyl]phenol, HCl
      DescriptionA potent antioxidant that readily crosses the blood-brain barrier. Significantly reduces ischemia-induced or hydrogen peroxide-induced neuronal damage. An inhibitor of lipid peroxidation (IC50 = 22 µM). Prevents nuclear translocation of activated NF-κB in hippocampal neurons.
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number141545-89-3
      Chemical formulaC₁₇H₂₉NO · HCl
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (100 mg/ml) or Methanol (100 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesToung, T.J., et al. 2000. Crit. Care Med. 28, 196.
      Fuson, K.S., et al. 1999. J. Neurochem. 72, 1154.
      Clemens, J.A., et al. 1998. Stroke 29, 677.
      Callaway, J.K., et al. 1998. J. Pharmacol. Toxicol. Methods 39, 155.
      O’Neill, M.J., et al. 1997. Brain Res. 760, 170.
      Clemens, J.A., et al. 1993. Stroke 24, 716.