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420202 JMJD Histone Demethylase Inhibitor III - CAS 1310809-17-6 - Calbiochem

The JMJD Histone Demethylase Inhibitor III controls the biological activity of JMJD Histone Demethylase. This small molecule/inhibitor is primarily used for Cell Structure applications.

JMJD Histone Demethylase Inhibitor III - CAS 1310809-17-6 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Histone Lysine Demethylase Inhibitor X, (E)-4-(Hydroxy(4-(4-((naphthalen-1-ylcarbamoyloxy)methyl)benzylamino)butyl)amino)-4-oxobut-2-enoic acid, JHDM Inhibitor III

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420202
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
1310809-17-6C₂₇H₂₉N₃O₆

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      Description
      OverviewA substrate (methyl lysine) and cofactor (α-ketoglutarate) mimicking bivalent benzylamino-butylamino-N-hydroxybutenoic acid compound that acts as a selective in vitro inhibitor of Jumonji domain-containing histone demethylases (JHDMs; IC50 = 4.3, 3.4, 5.9, 10 and 43 µM for JMJD2A, JMJD2C, JMJD2E, PHF8 and JMJD3, respectively) over LSD1, asparaginyl and prolyl hydroxylases, and histone deacetylases (IC50 = 54, 83, 31, 22, 620, 680 and >800 µM for PHD1, PHD2, PHD3, FIH, LSD1 and HDACs, respectively). The cellular active JHDM Inhibitor, Methylstat is also available (Cat. No. 420203).
      Catalogue Number420202
      Brand Family Calbiochem®
      SynonymsHistone Lysine Demethylase Inhibitor X, (E)-4-(Hydroxy(4-(4-((naphthalen-1-ylcarbamoyloxy)methyl)benzylamino)butyl)amino)-4-oxobut-2-enoic acid, JHDM Inhibitor III
      References
      ReferencesLuo, X., et al. 2011. J. Am. Chem. Soc. 133, 9451.
      Product Information
      CAS number1310809-17-6
      FormOff-white powder
      Hill FormulaC₂₇H₂₉N₃O₆
      Chemical formulaC₂₇H₂₉N₃O₆
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥95% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      420202-5MG 04055977210767

      Documentation

      JMJD Histone Demethylase Inhibitor III - CAS 1310809-17-6 - Calbiochem MSDS

      Title

      Safety Data Sheet (SDS) 

      JMJD Histone Demethylase Inhibitor III - CAS 1310809-17-6 - Calbiochem Certificates of Analysis

      TitleLot Number
      420202

      References

      Reference overview
      Luo, X., et al. 2011. J. Am. Chem. Soc. 133, 9451.

      Technical Info

      Title
      White Paper - The Message in the Marks: Deciphering Cancer Epigenetics
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision11-October-2012 JSW
      SynonymsHistone Lysine Demethylase Inhibitor X, (E)-4-(Hydroxy(4-(4-((naphthalen-1-ylcarbamoyloxy)methyl)benzylamino)butyl)amino)-4-oxobut-2-enoic acid, JHDM Inhibitor III
      DescriptionA substrate (methyl lysine) and cofactor (α-ketoglutarate) mimicking bivalent benzylamino-butylamino-N-hydroxybutenoic acid compound that acts as a selective in vitro inhibitor of Jumonji domain-containing histone demethylases (JHDMs; IC50 = 4.3, 3.4, 5.9, 10 and 43 µM for JMJD2A, JMJD2C, JMJD2E, PHF8 and JMJD3, respectively) over LSD1, asparaginyl and prolyl hydroxylases, and histone deacetylases (IC50 = 54, 83, 31, 22, 620, 680 and >800 µM for PHD1, PHD2, PHD3, FIH, LSD1 and HDACs, respectively). The cellular active JHDM Inhibitor, Methylstat is also available (Cat. No. 420203).
      FormOff-white powder
      Intert gas (Yes/No) Packaged under inert gas
      CAS number1310809-17-6
      Chemical formulaC₂₇H₂₉N₃O₆
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (100 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesLuo, X., et al. 2011. J. Am. Chem. Soc. 133, 9451.