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681676 InSolution™ Wortmannin - Calbiochem

Wortmannin is a fungal metabolite that acts as a potent, selective, cell-permeable and irreversible inhibitor of phosphatidylinositol 3-kinase (PI 3-kinase).

InSolution™ Wortmannin - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: MLCK Inhibitor II

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681676
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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₂₃H₂₄O₈

Pricing & Availability

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681676-1MG
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      		 Plastic ampoule 1 mg
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      Description
      Catalogue Number681676
      Brand Family Calbiochem®
      SynonymsMLCK Inhibitor II
      Application Data
      References
      ReferencesCross, M.J., et al. 1995. J. Biol. Chem. 270, 25352.
      Nakamura, I., et al. 1995. FEBS Lett. 361, 79.
      Ferby, I.M., et al. 1994. J. Biol. Chem. 269, 30485.
      Okada, T., et al. 1994. J. Biol. Chem. 269, 3568.
      Wymann, M.P. and Arcaro, A. 1994. Biochem. J. 298, 517.
      Arcaro, A. and Wymann, M.P. 1993. Biochem. J. 296, 297.
      Nakanishi, S., et al. 1992. J. Biol. Chem. 267, 2157.
      Bonser, R.W., et al. 1991. Br. J. Pharmacol. 103, 1237.
      Product Information
      FormLiquid
      FormulationA 10 mM (1 mg/233 µl) solution of Wortmannin (Cat. No. 681675) in DMSO.
      Hill FormulaC₂₃H₂₄O₈
      Chemical formulaC₂₃H₂₄O₈
      Hygroscopic Hygroscopic
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥95% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 21/22-36/38

      Harmful in contact with skin and if swallowed.
      Irritating to eyes and skin.
      S PhraseS: 24-26-36/37/39-45

      Avoid contact with skin.
      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing, gloves and eye/face protection.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped with Blue Ice or with Dry Ice
      Toxicity Harmful
      Storage -20°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      681676-1MG 04055977225242

      Documentation

      InSolution™ Wortmannin - Calbiochem MSDS

      Title

      Safety Data Sheet (SDS) 

      InSolution™ Wortmannin - Calbiochem Certificates of Analysis

      TitleLot Number
      681676

      References

      Reference overview
      Cross, M.J., et al. 1995. J. Biol. Chem. 270, 25352.
      Nakamura, I., et al. 1995. FEBS Lett. 361, 79.
      Ferby, I.M., et al. 1994. J. Biol. Chem. 269, 30485.
      Okada, T., et al. 1994. J. Biol. Chem. 269, 3568.
      Wymann, M.P. and Arcaro, A. 1994. Biochem. J. 298, 517.
      Arcaro, A. and Wymann, M.P. 1993. Biochem. J. 296, 297.
      Nakanishi, S., et al. 1992. J. Biol. Chem. 267, 2157.
      Bonser, R.W., et al. 1991. Br. J. Pharmacol. 103, 1237.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision03-November-2008 JSW
      SynonymsMLCK Inhibitor II
      Application Data
      DescriptionA fungal metabolite that acts as a potent, selective, cell-permeable and irreversible inhibitor of phosphatidylinositol 3-kinase (PI 3-kinase) in purified preparations and cytosolic fractions (IC50 = 5 nM). Preincubation of fibroblasts with wortmannin abolishes PDGF-mediated Ins(3,4,5)P3 formation (IC50 = 5 nM). Blocks the catalytic activity of PI 3-kinase without affecting the upstream signaling events. Also blocks the metabolic effects of insulin in isolated rat adipocytes without affecting the insulin receptor tyrosine kinase activity. Inhibits MAP kinase activation induced by platelet activating factor in guinea pig neutrophils (0.2-0.3 µM). Inhibits osteoclastic bone resorption. Inhibits other kinases, such as myosin light chain kinase (IC50 = 200 nM) and PI 4-kinase at concentrations 100-fold higher than that required for the inhibition of PI 3-kinase. Also blocks phospholipase D.
      FormLiquid
      FormulationA 10 mM (1 mg/233 µl) solution of Wortmannin (Cat. No. 681675) in DMSO.
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₂₃H₂₄O₈
      Purity≥95% by HPLC
      Storage Protect from light
      -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Toxicity Harmful
      Merck USA index14, 10053
      ReferencesCross, M.J., et al. 1995. J. Biol. Chem. 270, 25352.
      Nakamura, I., et al. 1995. FEBS Lett. 361, 79.
      Ferby, I.M., et al. 1994. J. Biol. Chem. 269, 30485.
      Okada, T., et al. 1994. J. Biol. Chem. 269, 3568.
      Wymann, M.P. and Arcaro, A. 1994. Biochem. J. 298, 517.
      Arcaro, A. and Wymann, M.P. 1993. Biochem. J. 296, 297.
      Nakanishi, S., et al. 1992. J. Biol. Chem. 267, 2157.
      Bonser, R.W., et al. 1991. Br. J. Pharmacol. 103, 1237.