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419840 ITSA1

A cell-permeable benzotriazole amide that counteracts and complements histone and tubulin deacetylase (HDAC and TDAC) inhibitors.

ITSA1 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Inhibitor of Trichostatin A 1, N-(1H-Benzotriazol-1-yl)-2,4-dichlorobenzamide

Primary Target: Tubulin acetylation mediated by Trichostatin A
419840
  
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      Overview

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      200626-61-5C₁₃H₇Cl₂N₃O
      Description
      Overview

      This product has been discontinued.





      A cell-permeable benzotriazole amide that counteracts and complements histone and tubulin deacetylase (HDAC and TDAC) inhibitors. Inhibits tubulin acetylation mediated by Trichostatin A, but not by Taxol. Through its successful use with TSA in vivo, it was shown that the expression of Rhodopsin-GFP transgene in Zebrafish eye is regulated via a mechanism involving reversible histone acetylation.
      Catalogue Number419840
      Brand Family Calbiochem®
      SynonymsInhibitor of Trichostatin A 1, N-(1H-Benzotriazol-1-yl)-2,4-dichlorobenzamide
      References
      ReferencesHaggarty, S.J., et al. 2003. Chem. Biol. 10, 383.
      Koeller, K.M., et al. 2003. Chem. Biol. 10, 397.
      Product Information
      CAS number200626-61-5
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₁₃H₇Cl₂N₃O
      Chemical formulaC₁₃H₇Cl₂N₃O
      ReversibleN
      Structure formula ImageStructure formula Image
      Applications
      Biological Information
      Primary TargetTubulin acetylation mediated by Trichostatin A
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Carcinogenic / Teratogenic
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      419840 0

      Documentation

      ITSA1 MSDS

      Title

      Safety Data Sheet (SDS) 

      ITSA1 Certificates of Analysis

      TitleLot Number
      419840

      References

      Reference overview
      Haggarty, S.J., et al. 2003. Chem. Biol. 10, 383.
      Koeller, K.M., et al. 2003. Chem. Biol. 10, 397.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision03-April-2008 RFH
      SynonymsInhibitor of Trichostatin A 1, N-(1H-Benzotriazol-1-yl)-2,4-dichlorobenzamide
      DescriptionA cell-permeable, benzotriazole amide that counteracts and complements histone deacetylase (HDAC) and tubulin deacetylase (TDAC) inhibitors in elucidating mechanisms of inhibition and the role of acetylation in various cellular responses, such as transcription, differentiation, cell cycle progression, and apoptosis. As a result of differential effects observed in A549 cells with ITSA1 on Trichostatin A (Cat. No. 647925) and taxol it has been confirmed that tubulin acetylation induced by these two inhibitors are mediated through different mechanisms in these cells. The administration of ITSA1 in combination with Trichostatin A in vivo demonstrated that the expression of a Rhodopsin-GFP transgene in the Zebrafish eye is regulated via a mechanism that involves reversible histone acetylation. Does not modify histone-acetyltransferases or affect levels of HDAC.
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number200626-61-5
      Chemical formulaC₁₃H₇Cl₂N₃O
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (5 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Carcinogenic / Teratogenic
      ReferencesHaggarty, S.J., et al. 2003. Chem. Biol. 10, 383.
      Koeller, K.M., et al. 2003. Chem. Biol. 10, 397.