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531399 IRE1 Inhibitor IV, A-106

A cell permeable compound that specifically targets the RNAse domain of IRE-1 (ERN1) and blocks the activation of X-box binding protein 1 (XBP-1).

IRE1 Inhibitor IV, A-106 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: ERN1 Inhibitor, A106

Primary Target: IRE1
531399
  
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      Overview

      Replacement Information

      Key Spec Table

      Empirical Formula
      C₁₁H₈O₂
      Description
      Overview

      This product has been discontinued.



      A cell permeable naphthaldehyde based compound that specifically targets the RNAse domain of IRE-1 (ERN1) and blocks the activation of X-box binding protein 1 (XBP-1). Shown to be equipotent to its parent compound, STF-083010. Blocks IRE-1 RNase activity via the formation of a stable Schiff base with K907 in the RNase domain of IRE-1, which prevents splicing of XBP-1mRNA. Downregulation of XBP-1 in Em-TCL1 CLL cells leads to apoptosis (~50 to 100 µM). Blocks the proliferation and survival of patient-derived pre-B ALL cells (10 to 50 thousand cells) in sub-lethally irradiated NOD/SCID mice in a dose-dependent manner.

      Please note that the molecular weight for this compound is batch-specific due to variable water content.

      Catalogue Number531399
      Brand Family Calbiochem®
      SynonymsERN1 Inhibitor, A106
      References
      ReferencesKriss, C., et al. 2012. Blood. 120, 1027. Masouleh, B. K., et al. 2014. PNAS. 111, in press.
      Product Information
      FormYellowish-white powder
      Hill FormulaC₁₁H₈O₂
      Chemical formulaC₁₁H₈O₂
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetIRE1
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      531399 0

      Documentation

      IRE1 Inhibitor IV, A-106 MSDS

      Title

      Safety Data Sheet (SDS) 

      IRE1 Inhibitor IV, A-106 Certificates of Analysis

      TitleLot Number
      531399

      References

      Reference overview
      Kriss, C., et al. 2012. Blood. 120, 1027. Masouleh, B. K., et al. 2014. PNAS. 111, in press.

      Brochure

      Title
      NPI Flyer- Epigenetics and Nuclear Function Feature
      New Products - Antibodies, Small Molecule, Inhibitors

      Technical Info

      Title
      White Paper: Further considerations of antibody validation and usage.