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412510 IRE1 Inhibitor I, STF-083010 - Calbiochem

IRE1 Inhibitor I, STF-083010, CAS 307543-71-1, is a cell-permeable compound that directly targets Ireα1 and disrupt Ire1-XBP1 unfolded protein response pathway in RPMI8226 multiple myeloma cells.

IRE1 Inhibitor I, STF-083010 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: N-[(2-Hydroxynaphthalen-1-yl)methylidene]thiophene-2-sulfonamide, N-[(2-Hydroxy-1-naphthyl)methylene]-2-thiophenesulfonamide, ER-to-Nucleus Signaling 1 Inhibitor I, ERN1 Inhibitor I, Inositol-Reguiring Protein 1 Inhibitor I, STF083010

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412510
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Overview

Key Spec Table

Empirical Formula
C₁₅H₁₁NO₃S₂

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412510-10MG
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      Description
      OverviewA cell-permeable salicylidene compound that is shown to directly target Ireα1 and disrupt Ire1-XBP1 (X-box binding protein) unfolded protein response (UPR) pathway in RPMI8226 multiple myeloma (MM) cells. Selectively inhibits ER stress-initiated endonuclease activity of Ire1 and blocks XPB1 mRNA splicing in MM cells at 60 µM and XBP1 activity in transgenic XBP1-luc mice (bortezomib 1mg/kg and 60 mg/kg of STF-083010, i.p.). Displays preferential cytotoxicity towards CD138+ cells over B, T and NK cells and antitumor properties.
      Catalogue Number412510
      Brand Family Calbiochem®
      SynonymsN-[(2-Hydroxynaphthalen-1-yl)methylidene]thiophene-2-sulfonamide, N-[(2-Hydroxy-1-naphthyl)methylene]-2-thiophenesulfonamide, ER-to-Nucleus Signaling 1 Inhibitor I, ERN1 Inhibitor I, Inositol-Reguiring Protein 1 Inhibitor I, STF083010
      References
      ReferencesLerner, A.G., et al. 2012 Cell Metabolism 16, 250.
      Papandreou, I., et al. 2010. Blood 117, )1311.
      Product Information
      FormYellow powder
      Hill FormulaC₁₅H₁₁NO₃S₂
      Chemical formulaC₁₅H₁₁NO₃S₂
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationIRE1 Inhibitor I, STF-083010, CAS 307543-71-1, is a cell-permeable compound that directly targets Ireα1 and disrupt Ire1-XBP1 unfolded protein response pathway in RPMI8226 multiple myeloma cells.
      Biological Information
      Purity≥98% by HPLC
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Regulatory Review
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsUnstable in solution; reconstitute just prior to use.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Catalogue Number GTIN
      412510-10MG 04055977188165