530536 Sigma-AldrichEGFR Activator, NSC 228155 - CAS 113104-25-9 - Calbiochem
A nitro-benzoxadiazole compound that directly binds to the dimerization domain of sEGF receptor to generate stable dimers and allosterically activate the receptor.
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Synonyms: 4-Nitro-7-((1-oxidopyridin-2-yl)sulfanyl)-2,1,3-benzoxadiazole, 4-Nitro-7-(1-oxy-pyridin-2-ylsulfanyl)-benzo[1,2,5]oxadiazole, 2-(7-Nitrobenzo[c][1,2,5]oxadiazol-4-ylthio)pyridine-1-oxide, NSC-228155
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Overview
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Key Spec Table
| CAS # | Empirical Formula |
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| 113104-25-9 | C₁₁H₆N₄O₄S |
Pricing & Availability
| Catalogue Number | Availability | Packaging | Qty/Pack | Price | Quantity | |
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| 5.30536.0001 |
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Glass bottle | 25 mg |
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| Description | |
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| Overview | A nitro-benzoxadiazole (NBD) compound that directly binds to the dimerization domain of sEGF receptor to generate stable dimers and allosterically activates the receptor. Exhibits similar phosphorylation profile as the cognate EGF-ligand. Enhances the phosphorylation of Tyr1068 and Tyr1173 in MDA-MB-468 cells in a time- and dose-dependent manner (EC50 = 52 µM with respect to Tyr1068). These phosphorylation events can be blocked by pre-incubating cells with AG1478 (Cat. No. 658852; 10 µM) or PD153035 (Cat. No. 234490; 2 µM) that selectively block the ATP-binding pocket of EGFR. Tyr1068 phosphorylation of the receptor can also be completely blocked in EGF treated MDA-MB-468 cells exposed to anti-EGFR neutralizing antibody. Please note that the molecular weight for this compound is batch-specific due to variable water content. |
| Catalogue Number | 530536 |
| Brand Family | Calbiochem® |
| Synonyms | 4-Nitro-7-((1-oxidopyridin-2-yl)sulfanyl)-2,1,3-benzoxadiazole, 4-Nitro-7-(1-oxy-pyridin-2-ylsulfanyl)-benzo[1,2,5]oxadiazole, 2-(7-Nitrobenzo[c][1,2,5]oxadiazol-4-ylthio)pyridine-1-oxide, NSC-228155 |
| References | |
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| References | Sakanyan, V., et al. 2014. Sci. Rep. 4, 3977. |
| Product Information | |
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| CAS number | 113104-25-9 |
| Form | Burnt orange powder |
| Hill Formula | C₁₁H₆N₄O₄S |
| Chemical formula | C₁₁H₆N₄O₄S |
| Hygroscopic | Hygroscopic |
| Quality Level | MQ100 |
| Applications |
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| Biological Information | |
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| Primary Target | EGF receptor |
| Purity | ≥97% by HPLC |
| Physicochemical Information | |
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| Cell permeable | Y |
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| Materials Information |
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| Toxicological Information |
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| Safety Information according to GHS |
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| Safety Information |
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| Product Usage Statements |
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| Packaging Information | |
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| Packaged under inert gas | Packaged under inert gas |
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| Specifications |
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| Global Trade Item Number | |
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| Catalogue Number | GTIN |
| 5.30536.0001 | 04055977260878 |
Documentation
EGFR Activator, NSC 228155 - CAS 113104-25-9 - Calbiochem MSDS
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References
| Reference overview |
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| Sakanyan, V., et al. 2014. Sci. Rep. 4, 3977. |
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Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
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