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240896 Cystatin C, Human Urine - Calbiochem

A low molecular weight non-glycosylated basic protein of the cystatin superfamily of cysteine protease inhibitors that it is freely filtered by the glomerular membrane.

Cystatin C, Human Urine - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Post γ-globulin

Primary Target: Cysteine protease
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      Overview

      Replacement Information
      Description
      OverviewA low molecular weight non-glycosylated basic protein of the cystatin superfamily of cysteine protease inhibitors that it is freely filtered by the glomerular membrane. Serum levels of cystatin C can be used as a specific and sensitive marker of glomerular filtration rate. Protects organisms against undesirable proteolysis by endogenous or exogenous enzymes. Thought to be linked to many disease processes including Alzheimer’s disease, hereditary cerebral hemorrhage, and lung cancer.
      Catalogue Number240896
      Brand Family Calbiochem®
      SynonymsPost γ-globulin
      References
      ReferencesHall, A., et al. 1998. Biochemistry 37, 4071.
      Peloille, S., et al. 1997. Eur. J. Biochem. 244, 140.
      Cimerman, N., et al. 1996. Biol. Chem. Hoppe Seyler 377, 19.
      Tenstad, O., et al. 1996. Scand. J. Clin. Lab. Invest. 56, 409.
      Product Information
      ATP CompetitiveN
      FormSolid
      FormulationLyophilized from 20 mM NH₄HCO₃.
      ReversibleN
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetCysteine protease
      Purity≥95% by SDS-PAGE
      SourcePrepared from the urine of patients with chronic renal tubular proteinuria that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, store in the refrigerator at 4°C. Stock solutions are stable for up to 2 month when stored at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      240896 0

      Documentation

      Cystatin C, Human Urine - Calbiochem MSDS

      Title

      Safety Data Sheet (SDS) 

      Cystatin C, Human Urine - Calbiochem Certificates of Analysis

      TitleLot Number
      240896

      References

      Reference overview
      Hall, A., et al. 1998. Biochemistry 37, 4071.
      Peloille, S., et al. 1997. Eur. J. Biochem. 244, 140.
      Cimerman, N., et al. 1996. Biol. Chem. Hoppe Seyler 377, 19.
      Tenstad, O., et al. 1996. Scand. J. Clin. Lab. Invest. 56, 409.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision12-June-2008 RFH
      SynonymsPost γ-globulin
      DescriptionA low molecular weight non-glycosylated basic protein of the cystatin superfamily of cysteine protease inhibitors that is freely filtered by the glomerular membrane. Serum levels of cystatin C can be used as a specific and sensitive marker of glomerular filtration rate. Protects organisms against undesirable proteolysis by endogenous or exogenous enzymes. Rapidly and tightly inhibits papain (Ki = 0.26 nM) and cathepsin B (Ki = 4.4 nM). Thought to be linked to many disease processes including Alzheimer's Disease, hereditary cerebral hemorrhage and lung cancer.
      FormSolid
      FormulationLyophilized from 20 mM NH₄HCO₃.
      SourcePrepared from the urine of patients with chronic renal tubular proteinuria that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
      Purity≥95% by SDS-PAGE
      Solubility0.1 M sodium acetate buffer, pH 4.5
      Storage +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, store in the refrigerator at 4°C. Stock solutions are stable for up to 2 month when stored at -20°C.
      Toxicity Standard Handling
      ReferencesHall, A., et al. 1998. Biochemistry 37, 4071.
      Peloille, S., et al. 1997. Eur. J. Biochem. 244, 140.
      Cimerman, N., et al. 1996. Biol. Chem. Hoppe Seyler 377, 19.
      Tenstad, O., et al. 1996. Scand. J. Clin. Lab. Invest. 56, 409.