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500112 Clorura de cocarboxilaza -

clorura esterului tiaminei cu acid difosforic, adecvata pentru utilizare ca ingredient farmaceutic activ EMPROVE® API

Clorura de cocarboxilaza - MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Thiaminium diphosphoric acid ester chloride, Thiaminium pyrophosphate chloride, Thiaminium pyrophosphoric acid ester chloride, TPP

CAS #: 154-87-0 EC Number: 205-836-1 Molar Mass: 460.80 g/mol Hill Formula: C₁₂H₁₉ClN₄O₇P₂S
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Overview

Replacement Information

Key Spec Table

CAS #EC NumberHill FormulaMolar Mass
154-87-0205-836-1C₁₂H₁₉ClN₄O₇P₂S460.80 g/mol

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              Description
              Catalogue Number500112
              SynonymsThiaminium diphosphoric acid ester chloride, Thiaminium pyrophosphate chloride, Thiaminium pyrophosphoric acid ester chloride, TPP
              References
              Product Information
              CAS number154-87-0
              EC number205-836-1
              Hill FormulaC₁₂H₁₉ClN₄O₇P₂S
              Molar Mass460.80 g/mol
              HS Code2936 22 90
              Structure formula ImageStructure formula Image
              Quality LevelMQ600
              Applications
              Biological Information
              Physicochemical Information
              Melting Point240 - 244 °C (descompunere)
              pH value2.2 (H₂O)
              Bulk density500 kg/m3
              Solubility220 g/l
              Dimensions
              Materials Information
              Toxicological Information
              Safety Information according to GHS
              Hazard Pictogram(s) Hazard Pictogram(s)
              Hazard Statement(s)H317: Poate provoca o reacţie alergică a pielii.
              Precautionary Statement(s)P261: Evitaţi să inspiraţi praful.
              P272: Nu scoateţi îmbrăcămintea de lucru contaminată în afara locului de muncă.
              P280: Purtaţi mănuşi de protecţie.
              P302 + P352: ÎN CAZ DE CONTACT CU PIELEA: spălați cu multă apă.
              P333 + P313: În caz de iritare a pielii sau de erupţie cutanată: consultaţi medicul.
              P362 + P364: Scoateți îmbrăcămintea contaminată și spalați-o înainte de reutilizare.
              Signal WordAtenţie
              RTECSXI7552000
              Storage class10 - 13 Alte lichide sau solide
              WGKWGK 1 slabă contaminare a apei
              Safety Information
              Product Usage Statements
              Storage and Shipping Information
              StorageA se depozita între +2°C la +25°C.
              Packaging Information
              Transport Information
              Supplemental Information
              Specifications
              Assay (HPLC, calc. on dried substance)≥ 93.0 %
              Appearance (color)white
              Appearance (description)crystalline powder
              Identity (IR-spectrum)conforms
              Identity (Cl)passes test
              Appearance of solution (10 %; water)clear,< colour reference solution Y7
              pH-value (10 %; water)1.0 - 1.4
              Chloride (Cl) (calculated on dried substance)7.5 - 7.9 %
              Free phosphate (PO₄)≤ 1.0 %
              Sulfate (SO₄)≤ 0.01 %
              Al (Aluminium) (#)≤ 0.0010 %
              As (Arsenic)≤ 0.0003 %
              Ni (Nickel) (#)≤ 0.0002 %
              Thiamin Monophosphoric Acid Ester Chloride (HPLC)≤ 4.0 %
              Thiamin Dichloride (HPLC)≤ 0.5 %
              Dithiamine Triphosphate (HPLC)≤ 0.20 %
              Impurity A (HPLC)≤ 0.1
              Impurity B (HPLC)≤ 0.1
              Related substances (HPLC)≤ 1.5 %
              Loss on drying (130 °C)≤ 1.5 %
              Endotoxins≤ 12 I.U./g
              Microbiological testpasses test
              Colony count (aerobic bacteria (TAMC))≤ 500 CFU/g
              Colony count (Yeasts and moulds (TYMC))≤ 100 CFU/g
              Salmonella speciesIn 10g substance not detectable
              E.coliIn 1g substance not detectable
              Staphylococcus aureusIn 1g substance not detectable
              Pseudomonas aeruginosaIn 1g substance not detectable
              Candida albicansIn 1g substance not detectable
              Residual solvents (Ph Eur/USP/ICH) class 2 (Methanol)≤ 2.0 %
              Other residual solvents (Ph Eur/USP/ICH)excluded by manufacturing process
              Elemental impurity specifications have been set considering ICH Q3D (Guideline for Elemental Impurities).
              Class 1-3 elements are not likely to be present above the ICH Q3D option 1 limit, unless specified and indicated (#).
              Residues of metal or metal reagents acc. to EMEA/CHMP/SWP/ 4446/2000 are not likely to be present.
              Global Trade Item Number
              Catalogue Number GTIN
              5001120100 04027269564223
              5001121000 04022536255934
              5001125000 04022536255972

              Documentation

              Emprove® API Information Package

              Title

              Clorura de cocarboxilaza - MSDS

              Title

              Safety Data Sheet (SDS) 

              Clorura de cocarboxilaza - Certificates of Analysis

              Product Number PackagingSpecificationLot Number
              5001120100 Plastic bottlePDF Specification Document
              5001121000 Plastic bottlePDF Specification Document
              5001125000 Plastic bottlePDF Specification Document

              Certificates

              Title