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208722 Calpain Inhibitor III - CAS 88191-84-8 - Calbiochem

Calpain Inhibitor III, CAS 88191-84-8, is a potent, cell-permeable inhibitor of calpain I and II (Ki = 8 nM).

Calpain Inhibitor III - CAS 88191-84-8 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Carbobenzoxy-valinyl-phenylalaninal, MDL 28170

Primary Target: calpain 1, calpain 2
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208722
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
88191-84-8C₂₂H₂₆N₂O₄

Pricing & Availability

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208722-25MG
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      		 Plastic ampoule 25 mg
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      Description
      OverviewA potent, cell-permeable inhibitor of calpain I and II (Ki = 8 nM). Reduces capsaicin-mediated cell death in cultured dorsal root ganglion. Reported to block A23187-induced suppression of neurite outgrowth in isolated hippocampal pyramidal neurons. Exhibits neuroprotective effect in glutamate-induced toxicity.
      Catalogue Number208722
      Brand Family Calbiochem®
      SynonymsCarbobenzoxy-valinyl-phenylalaninal, MDL 28170
      References
      ReferencesChatterjee, S., et al. 1998. J. Med. Chem. 41, 2663.
      Rami, A., et al. 1997. Neurosci. Res. 27, 93.
      Yamazaki, T., et al. 1997. Biochemistry 36, 8377.
      Klafki, H., et al. 1996. J. Biol. Chem. 271, 28655.
      Chard, P.S., et al. 1995. Neuroscience 65, 1099.
      Song, D.K., et al. 1994. J. Neurosci. Res. 39, 474.
      Product Information
      CAS number88191-84-8
      ATP CompetitiveN
      FormWhite lyophilized solid
      Hill FormulaC₂₂H₂₆N₂O₄
      Chemical formulaC₂₂H₂₆N₂O₄
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationCalpain Inhibitor III, CAS 88191-84-8, is a potent, cell-permeable inhibitor of calpain I and II (Ki = 8 nM).
      Biological Information
      Primary Targetcalpain 1, calpain 2
      Primary Target IC<sub>50</sub>8 nM
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Peptide SequenceZ-Val-Phe-CHO
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      208722-25MG 04055977202687

      Documentation

      Calpain Inhibitor III - CAS 88191-84-8 - Calbiochem MSDS

      Title

      Safety Data Sheet (SDS) 

      Calpain Inhibitor III - CAS 88191-84-8 - Calbiochem Certificates of Analysis

      TitleLot Number
      208722

      References

      Reference overview
      Chatterjee, S., et al. 1998. J. Med. Chem. 41, 2663.
      Rami, A., et al. 1997. Neurosci. Res. 27, 93.
      Yamazaki, T., et al. 1997. Biochemistry 36, 8377.
      Klafki, H., et al. 1996. J. Biol. Chem. 271, 28655.
      Chard, P.S., et al. 1995. Neuroscience 65, 1099.
      Song, D.K., et al. 1994. J. Neurosci. Res. 39, 474.

      Brochure

      Title
      Caspases and other Apoptosis Related Tools Brochure

      Citations

      Title
    • Dong, Y., et al. 2009. J. Cell Mol. Med. 13, 2899.
    • Dong, Y., et al. 2006. FASEB Journal in press,.
    • So-Young Park and Adriana Ferreira. 2005. Journal of Neuroscience 25, 5365.
    • Rios-Doria, J., et al. 2004. Cancer Research 64, 7237.
      		•
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision28-May-2008 RFH
      SynonymsCarbobenzoxy-valinyl-phenylalaninal, MDL 28170
      DescriptionA potent, cell-permeable inhibitor of calpain I and II (Ki = 8 nM) that also reduces capsaicin-mediated cell death in cultured dorsal root ganglion. Reported to block A23187-induced suppression of neurite outgrowth in isolated hippocampal pyramidal neurons. Exhibits neuroprotective effects against glutamate-induced toxicity.
      FormWhite lyophilized solid
      CAS number88191-84-8
      Chemical formulaC₂₂H₂₆N₂O₄
      Peptide SequenceZ-Val-Phe-CHO
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (20 mg/ml). Use only anhydrous DMSO.
      Storage +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Toxicity Standard Handling
      ReferencesChatterjee, S., et al. 1998. J. Med. Chem. 41, 2663.
      Rami, A., et al. 1997. Neurosci. Res. 27, 93.
      Yamazaki, T., et al. 1997. Biochemistry 36, 8377.
      Klafki, H., et al. 1996. J. Biol. Chem. 271, 28655.
      Chard, P.S., et al. 1995. Neuroscience 65, 1099.
      Song, D.K., et al. 1994. J. Neurosci. Res. 39, 474.
      Citation
    • Dong, Y., et al. 2009. J. Cell Mol. Med. 13, 2899.
    • Dong, Y., et al. 2006. FASEB Journal in press,.
    • So-Young Park and Adriana Ferreira. 2005. Journal of Neuroscience 25, 5365.
    • Rios-Doria, J., et al. 2004. Cancer Research 64, 7237.
      		•

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      Categories

      Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Proteases Inhibitors > Calpain Inhibitors