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509890 Benztropine - CAS 132-17-2 - Calbiochem

An antagonist of muscarinic M1 and M3 receptors that induces robust differentiation of oligodendrocytes precursor cell differentiation (EC₅₀ = 500 nM) and promotes myelination.

Benztropine - CAS 132-17-2 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Benzatropine, Cogentin

Primary Target: Muscarinic M1/M3
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509890
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
132-17-2C₂₁H₂NO·CH₃SO₃H

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      Description
      OverviewA brain penetrating azabicyclo[3.2.1]octane derivative with anti-cholinergic and anti-histaminergic properties. Acts as an antagonist of muscarinic M1 and M3 receptors induces robust differentiation of oligodendrocytes precursor cell differentiation (OPC; EC50 = 500 nM) and promotes myelination. Reduces the expression of Notch 1 in immature OPC and reduces the levels of cyclin D1 and D2 and c-Fos and c-Jun indicating its inhibitory effect on cell cycle progression. Shown to reduce the severity of the acute phase of multiple sclerosis and virtually eliminates the relapse phase in animal models. Significantly reduces the severity in the experimental autoimmune encephalomyelitis (EAE) model of relapsing-remitting multiple sclerosis when administered alone or co-administered with FTY720 (Cat. No. 344597).
      Catalogue Number509890
      Brand Family Calbiochem®
      SynonymsBenzatropine, Cogentin
      References
      ReferencesDeshmukh, V.A, et al. 2013. Nature 502,327.
      Doshay, L.J., et al. 1956. J Am Med Assoc. 162, 1031.
      Product Information
      CAS number132-17-2
      FormWhite solid
      Hill FormulaC₂₁H₂NO·CH₃SO₃H
      Chemical formulaC₂₁H₂NO·CH₃SO₃H
      ReversibleY
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetMuscarinic M1/M3
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 25

      Toxic if swallowed.
      S PhraseS: 36-45

      Wear suitable protective clothing.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Toxic
      Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      5.09890.0001 04055977241167

      Documentation

      Benztropine - CAS 132-17-2 - Calbiochem MSDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      Deshmukh, V.A, et al. 2013. Nature 502,327.
      Doshay, L.J., et al. 1956. J Am Med Assoc. 162, 1031.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision28-April-2014 JSW
      SynonymsBenzatropine, Cogentin
      DescriptionA brain penetrating azabicyclo[3.2.1]octane derivative with anti-cholinergic and anti-histaminergic properties. Acts as an antagonist of muscarinic M1 and M3 receptors induces robust differentiation of oligodendrocytes precursor cell differentiation (OPC; EC50 = 500 nM) and promotes myelination. Reduces the expression of Notch 1 in immature OPC and reduces the levels of cyclin D1 and D2 and c-Fos and c-Jun indicating its inhibitory effect on cell cycle progression. Shown to reduce the severity of the acute phase of multiple sclerosis and virtually eliminates the relapse phase in animal models. Significantly reduces the severity in the experimental autoimmune encephalomyelitis (EAE) model of relapsing-remitting multiple sclerosis when administered alone or co-administered with FTY720 (Cat. No. 344597).
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number132-17-2
      Chemical formulaC₂₁H₂NO·CH₃SO₃H
      Purity≥98% by HPLC
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Toxic
      ReferencesDeshmukh, V.A, et al. 2013. Nature 502,327.
      Doshay, L.J., et al. 1956. J Am Med Assoc. 162, 1031.