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07-804 Anti-phospho-c-Kit (Tyr721) Antibody

This Anti-phospho-c-Kit (Tyr721) Antibody is validated for use in WB for the detection of phospho-c-Kit (Tyr721).

Anti-phospho-c-Kit (Tyr721) Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Signaling Research Sub-Category: Growth Factors & Receptors Gene Symbol: KIT, C-Kit, PBT, CD117, SCFR, c-kit UniProt Number: P10721
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07-804
100 µL  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWBRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue Number07-804
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-phospho-c-Kit (Tyr721) Antibody
      Alternate Names
      • KIT
      • CD117
      • PBT
      • SCFR
      • v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
      References
      Product Information
      FormatAffinity Purified
      Presentation100 μL of affinity purified rabbit polyclonal IgG in 50% storage buffer (PBS (without Mg2+ and Ca2+), pH 7.3 containing 1.0 mg/mL BSA (IgG, protease free) and 0.05% sodium azide) and 50% glycerol.
      Quality LevelMQ100
      Applications
      ApplicationThis Anti-phospho-c-Kit (Tyr721) Antibody is validated for use in WB for the detection of phospho-c-Kit (Tyr721).
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenPeptide corresponding to amino acid region encompassing the human phospho-c-Kit (Tyr721).
      HostRabbit
      SpecificityRecognizes phosphorylated c-Kit (Tyr721)
      IsotypeIgG
      Species Reactivity
      • Human
      Species Reactivity NoteMouse and Rat have not been tested, but are expected to react based on sequence similarity.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes the human homolog of the proto-oncogene c-kit. C-kit was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. This protein is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). Mutations in this gene are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous lukemia, and piebaldism. Multiple transcript variants encoding different isoforms have been found for this gene.
      Gene Symbol
      • KIT
      • C-Kit
      • PBT
      • CD117
      • SCFR
      • c-kit
      Modifications
      • Phosphorylation
      Purification MethodImmunoAffinity Purified
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P10721 # This is the receptor for stem cell factor (mast cell growth factor). It has a tyrosine-protein kinase activity. Binding of the ligands leads to the autophosphorylation of KIT and its association with substrates such as phosphatidylinositol 3-kinase (Pi3K).
      SIZE: 976 amino acids; 109865 Da
      SUBUNIT: Interacts with APS. Interacts with the tenth PDZ domain of MPDZ.
      SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
      DISEASE: SwissProt: P10721 # Defects in KIT are a cause of piebaldism [MIM:172800]. Piebaldism is an autosomal dominant genetic developmental abnormality of pigmentation characterized by congenital patches of white skin and hair that lack melanocytes. & Defects in KIT are a cause of gastrointestinal stromal tumor (GIST) [MIM:606764]. & Defects in KIT have been associated with testicular tumors [MIM:273300]. It includes germ cell tumor (GCT) or testicular germ cell tumor (TGCT).
      SIMILARITY: SwissProt: P10721 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. & Contains 5 Ig-like C2-type (immunoglobulin-like) domains. & Contains 1 protein kinase domain.
      Molecular Weight145 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated by immunoblot.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 2 years at -20°C from date of shipment.
      Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerolcontaining solutions to become frozen during storage.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      07-804 04053252334078

      Documentation

      Anti-phospho-c-Kit (Tyr721) Antibody MSDS

      Title

      Safety Data Sheet (SDS) 

      Anti-phospho-c-Kit (Tyr721) Antibody Certificates of Analysis

      TitleLot Number
      Anti-phospho-c-Kit (Tyr721) (Affinity purified Rabbit polyclonal IgG) 2865958
      Anti-phospho-c-Kit (Tyr721) (Affinity purified Rabbit polyclonal IgG) - 2062295 2062295
      Anti-phospho-c-Kit (Tyr721) (Affinity purified Rabbit polyclonal IgG) - 2345559 2345559
      Anti-phospho-c-Kit (Tyr721) - 0604027374 0604027374
      Anti-phospho-c-Kit (Tyr721) - 3922560 3922560

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies