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PC563 Anti-hTERT (348-358) Rabbit pAb

This Anti-hTERT (348-358) Rabbit pAb is validated for use in Paraffin Sections, Immunoblotting, Immunofluorescence for the detection of hTERT (348-358).

Anti-hTERT (348-358) Rabbit pAb MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
PC563
  
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      Overview

      Replacement Information

      Key Spec Table

      Host
      Rb
      Description
      OverviewRecognizes the ~128 kDa hTERT protein in human breast carcinoma.

      This product has been discontinued.
      Catalogue NumberPC563
      Brand Family Calbiochem®
      Application Data
      Detection of hTERT by staining paraffin sections. Sample: Human breast carcinoma. Primary antibody: Anti-hTERT (348-358) Rabbit pAb (Cat. No. PC563) (2.5 μg/ml). Detection: DAB with methyl green counterstain.
      References
      ReferencesDe Kok, J.B., et al. 2000. Int. J. Cancer 87, 217.
      Kelland, L.R. 2000. Anticancer Drugs 11, 503.
      Nowak, J.A. 2000. Clin. Lab. Med. 20, 369.
      Kang, S.S., et al. 1999. J. Biol. Chem. 274, 13085.
      Nagao, K., et al. 1999. J. Gastroenterol. 34, 83.
      Park, T.W., et al. 1999. Int. J. Cancer 84, 426.
      Saji, M., et al. 1999. Clin. Cancer Res. 5, 1483.
      Yi, X., et al. 1999. Mol. Cell. Biol. 19, 1989.
      Counter, C.M., et al. 1998. Oncogene 16, 1217.
      Meyerson, M. 1998. Toxicol. Lett. 41, 102.
      Ulanar, G.A., et al. 1998. Cancer Res. 58, 4168.
      Product Information
      FormLiquid
      FormulationIn 50 mM sodium phosphate buffer, 50% glycerol, pH 7.5.
      Positive controlHuman breast carcinoma tissue
      PreservativeNone
      Applications
      Key Applications Not Western Blot
      Not Immunofluorescence
      Paraffin Sections
      Application NotesParaffin Sections (2.5 µg/ml, pressure cooker pre-treatment required)
      Immunoblotting (not recommended)
      Immunofluorescence (not recommended)
      Application CommentsAntibody should be titrated for optimal results in individual systems.
      Biological Information
      Immunogena synthetic peptide corresponding to amino acids 348-358 of human hTERT
      ImmunogenHuman
      HostRabbit
      IsotypeIgG
      Concentration Label Please refer to vial label for lot-specific concentration
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Standard Handling
      Storage -20°C
      Avoid freeze/thaw Avoid freeze/thaw
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      PC563 0

      Documentation

      Anti-hTERT (348-358) Rabbit pAb MSDS

      Title

      Safety Data Sheet (SDS) 

      Anti-hTERT (348-358) Rabbit pAb Certificates of Analysis

      TitleLot Number
      PC563

      References

      Reference overview
      De Kok, J.B., et al. 2000. Int. J. Cancer 87, 217.
      Kelland, L.R. 2000. Anticancer Drugs 11, 503.
      Nowak, J.A. 2000. Clin. Lab. Med. 20, 369.
      Kang, S.S., et al. 1999. J. Biol. Chem. 274, 13085.
      Nagao, K., et al. 1999. J. Gastroenterol. 34, 83.
      Park, T.W., et al. 1999. Int. J. Cancer 84, 426.
      Saji, M., et al. 1999. Clin. Cancer Res. 5, 1483.
      Yi, X., et al. 1999. Mol. Cell. Biol. 19, 1989.
      Counter, C.M., et al. 1998. Oncogene 16, 1217.
      Meyerson, M. 1998. Toxicol. Lett. 41, 102.
      Ulanar, G.A., et al. 1998. Cancer Res. 58, 4168.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision07-August-2007 JSW
      ApplicationParaffin Sections (2.5 µg/ml, pressure cooker pre-treatment required)
      Immunoblotting (not recommended)
      Immunofluorescence (not recommended)
      Application Data
      Detection of hTERT by staining paraffin sections. Sample: Human breast carcinoma. Primary antibody: Anti-hTERT (348-358) Rabbit pAb (Cat. No. PC563) (2.5 μg/ml). Detection: DAB with methyl green counterstain.
      DescriptionPurified rabbit polyclonal antibody. Recognizes the ~128 kDa hTERT protein.
      BackgroundHuman telomerase is composed of three major components–an RNA component (hTERC), and two protein components, telomerase-associated protein (TEP-1) and telomerase reverse transcriptase (hTERT). The hTERT subunit (approximately 128 kDa) is also the catalytic subunit of telomerase. Selective activation of the hTERT subunit has been demonstrated in the majority of tumors relative to its expression in uninvolved somatic cells making it an attractive target for rational drug design. Expression of the hTERT gene product has been documented in a variety of cancers including urothelial cell carcinoma, ovarian tumors, thyroid neoplasia, and hepatocellular carcinoma to name a few. Levels of hTERT RNA and hTERT protein are regulated by a number of mechanisms including both transcriptional and post-translational mechanisms as well as by the activity of other proteins such as the AKT protein.
      HostRabbit
      Immunogen speciesHuman
      Immunogena synthetic peptide corresponding to amino acids 348-358 of human hTERT
      IsotypeIgG
      Specieshuman, not mouse
      Positive controlHuman breast carcinoma tissue
      FormLiquid
      FormulationIn 50 mM sodium phosphate buffer, 50% glycerol, pH 7.5.
      Concentration Label Please refer to vial label for lot-specific concentration
      PreservativeNone
      CommentsAntibody should be titrated for optimal results in individual systems.
      Storage Avoid freeze/thaw
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Toxicity Standard Handling
      ReferencesDe Kok, J.B., et al. 2000. Int. J. Cancer 87, 217.
      Kelland, L.R. 2000. Anticancer Drugs 11, 503.
      Nowak, J.A. 2000. Clin. Lab. Med. 20, 369.
      Kang, S.S., et al. 1999. J. Biol. Chem. 274, 13085.
      Nagao, K., et al. 1999. J. Gastroenterol. 34, 83.
      Park, T.W., et al. 1999. Int. J. Cancer 84, 426.
      Saji, M., et al. 1999. Clin. Cancer Res. 5, 1483.
      Yi, X., et al. 1999. Mol. Cell. Biol. 19, 1989.
      Counter, C.M., et al. 1998. Oncogene 16, 1217.
      Meyerson, M. 1998. Toxicol. Lett. 41, 102.
      Ulanar, G.A., et al. 1998. Cancer Res. 58, 4168.