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MABC536 Anti-Vasohibin-2, clone 5E3 Antibody

Anti-Vasohibin-2 antibody, clone 5E3 is an antibody against Vasohibin-2 for use in western blotting & IHC.

Anti-Vasohibin-2, clone 5E3 Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Apoptosis & Cancer Research Sub-Category: Apoptosis - Additional Gene Symbol: VASH2, VASHL UniProt Number: Q86V25
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MABC536
100 µg  
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      Overview

      Replacement Information

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, MWB, IHCMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABC536
      DescriptionAnti-Vasohibin-2, clone 5E3 Antibody
      Alternate Names
      • Vasohibin-2
      • Vasohibin-like protein
      Background InformationVasohibin-2, also known as Vasohibin-like protein, and encoded by the gene VASH2/VASHL, is a developmental regulator protein of angiogenesis induced by VEGF and present in various embryonic organs at six to 12 twelve weeks of development in humans. Vasohibin-2 acts as an angiogenesis inhibitor and is thought to help regulate organ vessel formation and maturation. In cancer, Vascohibin-2 appears to act to promote angiogenesis and is expressed in many cancers. In cancer cells, there are two isoforms. VASH2 (with 355 amino acid residues) is located in the cytoplasm while VASH2 (with 311 amino acid residues) is located in the nucleus. The former was found to be a relatively low abundance protein.
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal IgG1κ in buffer containing PBS without preservatives .
      Quality LevelMQ100
      Applications
      ApplicationAnti-Vasohibin-2 antibody, clone 5E3 is an antibody against Vasohibin-2 for use in western blotting & IHC.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      Application NotesImmunohistochemistry Analysis: A 1:2,000 dilution from a representative lot detected Vasohibin 2 in human placenta tissue.
      Immunohistochemistry Analysis: A representative lot detected Vasohibin 2 in human and mouse embryonic lung tissue (Shibuya, T., et al. (2006). American Heart Association. 26:1051-1057).
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to human Vasohibin 2.
      Clone5E3
      Concentration1 mg/mL
      HostMouse
      IsotypeIgG1κ
      Species Reactivity
      • Human
      • Mouse
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • VASH2
      • VASHL
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight~40 kDa observed. Uncharacterized band(s) may appear in some lysates.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in HUVEC cell lysate.

      Western Blotting Analysis: 0.5 µg/mL of this antibody detected Vasohibin 2 in 10 µg of HUVEC cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at -20°C from date of receipt.
      Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
      Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      MABC536 04053252975752

      Documentation

      Anti-Vasohibin-2, clone 5E3 Antibody MSDS

      Title

      Safety Data Sheet (SDS) 

      Anti-Vasohibin-2, clone 5E3 Antibody Certificates of Analysis

      TitleLot Number
      Anti-Vasohibin-2, clone 5E3 3083528
      Anti-Vasohibin-2, clone 5E3 - Q2426884 Q2426884
      Anti-Vasohibin-2, clone 5E3 - 3229377 3229377
      Anti-Vasohibin-2, clone 5E3 - 3385863 3385863
      Anti-Vasohibin-2, clone 5E3 - 3819208 3819208
      Anti-Vasohibin-2, clone 5E3 - 3862697 3862697
      Anti-Vasohibin-2, clone 5E3 - 4159886 4159886
      Anti-Vasohibin-2, clone 5E3 -2717553 2717553
      Anti-Vasohibin-2, clone 5E3 Monoclonal Antibody 2923051
      Anti-Vasohibin-2, clone 5E3 Monoclonal Antibody 3559007

      References

      Reference overviewPub Med ID
      Isolation and characterization of vasohibin-2 as a homologue of VEGF-inducible endothelium-derived angiogenesis inhibitor vasohibin.
      Shibuya, Takumi, et al.
      Arterioscler. Thromb. Vasc. Biol., 26: 1051-7 (2006)  2006

      Show Abstract       		16528006 16528006