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OP185 Anti-Toll-Like Receptor 9 (Ab-1) Mouse mAb (26C593)

Anti-Toll-Like Receptor 9 (Ab-1) Mouse mAb (26C593) MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Anti-TLR9

OP185
  
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      Overview

      Replacement Information

      Key Spec Table

      Host
      M
      Description
      Overview

      This product has been discontinued.





      Recognizes the ~120 kDa TLR9 protein in human peripheral blood mononuclear cells and Ramos.
      Catalogue NumberOP185
      Brand Family Calbiochem®
      SynonymsAnti-TLR9
      Application Data
      Detection of toll-like receptor 9 by immunoblotting. Samples: Tissue lysates from human PBMC (lane 1), human intestine (lane 2), mouse intestine (lane 3), and rat intestine (lane 4). Primary antibody: Anti-Toll-Like Receptor 9 (Ab-1) Mouse mAb (26C593) (Cat. No. OP185) (3 µg/ml). Detection: chemiluminescence.
      References
      ReferencesChuang, T.H., and Ulevitch, R.J., 2001. Biochim. Biophys. Acta 1518, 157.
      Hemmi, H., et al. 2000. Nature 408, 740.
      Takeuchi, O., et al. 1999 Gene 231, 59.
      Muzio, M., et al. 1998. J. Exp. Med. 187, 2097.
      Medzhitov, R., and Janeway, C.A., 1997. Cell 91, 295.
      Product Information
      FormLiquid
      FormulationIn PBS containing 0.2% gelatin.
      Positive controlHuman peripheral blood mononuclear cell lysate or Ramos cells
      Preservative≤0.1% sodium azide
      Applications
      Key Applications Flow Cytometry
      Immunoblotting (Western Blotting)
      Application NotesFlow Cytometry (assay dependent)
      Immunoblotting (assay dependent)
      Application CommentsAntibody should be titrated for optimal results in individual systems.
      Biological Information
      Immunogena synthetic peptide corresponding to amino acids in a unique region of toll-like receptor 9, conjugated to KLH
      ImmunogenHuman
      Clone26C593
      HostMouse
      IsotypeIgG₁
      Concentration Label Please refer to vial label for lot-specific concentration
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Blue Ice Only
      Toxicity Standard Handling
      Storage -20°C
      Avoid freeze/thaw Avoid freeze/thaw
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      OP185 0

      Documentation

      Anti-Toll-Like Receptor 9 (Ab-1) Mouse mAb (26C593) MSDS

      Title

      Safety Data Sheet (SDS) 

      Anti-Toll-Like Receptor 9 (Ab-1) Mouse mAb (26C593) Certificates of Analysis

      TitleLot Number
      OP185

      References

      Reference overview
      Chuang, T.H., and Ulevitch, R.J., 2001. Biochim. Biophys. Acta 1518, 157.
      Hemmi, H., et al. 2000. Nature 408, 740.
      Takeuchi, O., et al. 1999 Gene 231, 59.
      Muzio, M., et al. 1998. J. Exp. Med. 187, 2097.
      Medzhitov, R., and Janeway, C.A., 1997. Cell 91, 295.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision02-October-2007 RFH
      SynonymsAnti-TLR9
      ApplicationFlow Cytometry (assay dependent)
      Immunoblotting (assay dependent)
      Application Data
      Detection of toll-like receptor 9 by immunoblotting. Samples: Tissue lysates from human PBMC (lane 1), human intestine (lane 2), mouse intestine (lane 3), and rat intestine (lane 4). Primary antibody: Anti-Toll-Like Receptor 9 (Ab-1) Mouse mAb (26C593) (Cat. No. OP185) (3 µg/ml). Detection: chemiluminescence.
      DescriptionPurified mouse monoclonal antibody. Recognizes the ~120 kDa TLR9 protein.
      BackgroundThe mammalian Toll-like receptor (TLR) family is comprised of a group of transmembrane proteins characterized by multiple copies of leucine-rich repeats in the extracellular domain, and an IL-1 receptor motif in the cytoplasmic domain. TLRs signal through adaptor molecules and may be an important component of innate immunity in humans. The TRL family is a phylogenetically conserved mediator of innate immunity and is essential to microbial recognition. TLRs characterized in the past have been shown to activate the MyD88/interleukin -1 receptor-associated kinase (IRAK) signaling pathway. Ten homologs of TLRs (TLR1-TLR10) have previously been described and the cDNA coding for TLR9 has been identified and isolated. Research has shown that TRL9 acts as a receptor for unmethylated CpG dinucleotides in bacterial DNA. Human and mouse TLR9 share an amino acid identity of 75.5%, and it is highly expressed in the spleen.
      HostMouse
      Immunogen speciesHuman
      Immunogena synthetic peptide corresponding to amino acids in a unique region of toll-like receptor 9, conjugated to KLH
      Clone26C593
      IsotypeIgG₁
      Specieshuman
      Positive controlHuman peripheral blood mononuclear cell lysate or Ramos cells
      FormLiquid
      FormulationIn PBS containing 0.2% gelatin.
      Concentration Label Please refer to vial label for lot-specific concentration
      Preservative≤0.1% sodium azide
      CommentsAntibody should be titrated for optimal results in individual systems.
      Storage Avoid freeze/thaw
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Toxicity Standard Handling
      ReferencesChuang, T.H., and Ulevitch, R.J., 2001. Biochim. Biophys. Acta 1518, 157.
      Hemmi, H., et al. 2000. Nature 408, 740.
      Takeuchi, O., et al. 1999 Gene 231, 59.
      Muzio, M., et al. 1998. J. Exp. Med. 187, 2097.
      Medzhitov, R., and Janeway, C.A., 1997. Cell 91, 295.