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GF53 Anti-Tissue Plasminogen Activator (Ab-1) Mouse mAb (GMA-043)

This Anti-Tissue Plasminogen Activator (Ab-1) Mouse mAb (GMA-043) is validated for use in ELISA, Immunoblotting for the detection of Tissue Plasminogen Activator (Ab-1).

Anti-Tissue Plasminogen Activator (Ab-1) Mouse mAb (GMA-043) MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
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GF53
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Overview

Replacement Information

Key Spec Table

Species ReactivityHostAntibody Type
HMMonoclonal Antibody

Pricing & Availability

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GF53-100UG
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      		 Plastic ampoule 100 μg
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      Description
      OverviewRecognizes the ~60 kDa tPA protein.
      Catalogue NumberGF53
      Brand Family Calbiochem®
      Application Data
      Detection of human tissue plasminogen activator by immunoblotting. Sample: Tissue from human plasminogen activator protein. Primary antibody: Anti-Tissue Plasminogen Activator (Ab-1) Mouse mAb (GMA-043) (Cat. No. GF53) (1 µg/ml). Detection: chemiluminescence.
      References
      ReferencesHartleib, J., et al. 2000. Blood 96, 2149.
      Wiman, B., et al. 2000. Arterioscler Thromb. Vasc. Biol. 20, 2019.
      Pourtau, J., et al. 1998. Blood Coagul Fibrinolysis 9, 609.
      Van, D.E., et al. 1995. Blood 85, 3510.
      Product Information
      FormLiquid
      FormulationIn 150 mM NaCl, 10 mM sodium phosphate, 1% mannitol, pH 7.4.
      Positive controlHuman tPA
      PreservativeNone
      Quality LevelMQ100
      Applications
      Key Applications Enzyme-Linked Immunosorbent Assay
      Immunoblotting (Western Blotting)
      Application NotesELISA (1-5 µg/ml)
      Immunoblotting (1-5 µg/ml)
      Application CommentsAntibody should be titrated for optimal results in individual systems.
      Biological Information
      Immunogenpurified human tissue plasminogen activator (tPA)
      ImmunogenHuman
      CloneGMA-043
      HostMouse
      IsotypeIgG₁
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Concentration Label Please refer to vial label for lot-specific concentration
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Standard Handling
      Storage -20°C
      Avoid freeze/thaw Avoid freeze/thaw
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°).
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      GF53-100UG 04055977220148

      Documentation

      Anti-Tissue Plasminogen Activator (Ab-1) Mouse mAb (GMA-043) MSDS

      Title

      Safety Data Sheet (SDS) 

      Anti-Tissue Plasminogen Activator (Ab-1) Mouse mAb (GMA-043) Certificates of Analysis

      TitleLot Number
      GF53

      References

      Reference overview
      Hartleib, J., et al. 2000. Blood 96, 2149.
      Wiman, B., et al. 2000. Arterioscler Thromb. Vasc. Biol. 20, 2019.
      Pourtau, J., et al. 1998. Blood Coagul Fibrinolysis 9, 609.
      Van, D.E., et al. 1995. Blood 85, 3510.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision24-August-2007 RFH
      ApplicationELISA (1-5 µg/ml)
      Immunoblotting (1-5 µg/ml)
      Application Data
      Detection of human tissue plasminogen activator by immunoblotting. Sample: Tissue from human plasminogen activator protein. Primary antibody: Anti-Tissue Plasminogen Activator (Ab-1) Mouse mAb (GMA-043) (Cat. No. GF53) (1 µg/ml). Detection: chemiluminescence.
      DescriptionPurified mouse monoclonal antibody. Recognizes the ~60 kDa tPA protein.
      BackgroundEpidemiological studies have demonstrated that levels of plasma fibrinogen, von Willebrand factor (vWf), plasminogen activator inhibitor-1 (PAI-1) and tissue-type plasminogen activator (tPA) are associated with the incidence of vascular disease. Von Willebrand factor (vWF) is a large, multimeric glycoprotein mediating platelet adhesion at sites of endothelial damage. The process of acute release of tissue-type plasminogen activator (tPA) is important in locally speeding up fibrinolysis. Acutely released tPA and constitutively secreted tPA were liberated from different pathways in human umbilical vein endothelial cells. Plasma levels of tissue plasminogen activator to plasminogen activator/ inhibitor-1 complex, in addition to von Willebrand factor, are significant risk markers for recurrent myocardial infarction.
      HostMouse
      Immunogen speciesHuman
      Immunogenpurified human tissue plasminogen activator (tPA)
      CloneGMA-043
      IsotypeIgG₁
      Specieshuman
      Positive controlHuman tPA
      FormLiquid
      FormulationIn 150 mM NaCl, 10 mM sodium phosphate, 1% mannitol, pH 7.4.
      Concentration Label Please refer to vial label for lot-specific concentration
      PreservativeNone
      CommentsAntibody should be titrated for optimal results in individual systems.
      Storage Avoid freeze/thaw
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°).
      Toxicity Standard Handling
      ReferencesHartleib, J., et al. 2000. Blood 96, 2149.
      Wiman, B., et al. 2000. Arterioscler Thromb. Vasc. Biol. 20, 2019.
      Pourtau, J., et al. 1998. Blood Coagul Fibrinolysis 9, 609.
      Van, D.E., et al. 1995. Blood 85, 3510.