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MABF2241-25UL Anti-NKp30 Antibody, clone 30.95.1

Anti-NKp30, clone 30.95.1, Cat. No. MABF2241, is a mouse monoclonal antibody that detects Natural cytotoxicity triggering receptor 3 (NKp30) and is tested for use in Flow Cytometry.

MABF2241-25UL
25 µL  
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      Overview

      Replacement Information
      Description
      Catalogue NumberMABF2241-25UL
      DescriptionAnti-NKp30 Antibody, clone 30.95.1
      Alternate Names
      • Natural cytotoxicity triggering receptor 3
      • Activating natural killer receptor p30
      • Natural killer cell p30-related protein
      • NK-p30
      • CD337
      Background InformationNatural cytotoxicity triggering receptor 3 (UniProt: O14931; also known as Activating natural killer receptor p30, Natural killer cell p30-related protein, NK-p30, NKp30, CD337) is encoded by the NCR3 (also known as 1C7, LY117) gene (Gene ID: 259197) in human. NKp30 is a single-pass type I membrane protein that is selectively expressed by all resting and activated NK cells. Its weaker expression is observed in spleen. It serves as a receptor of natural killer/NK cell. It is activated by binding of extracellular ligands including BAG6 and NCR3LG1. It stimulates NK cells cytotoxicity toward neighboring cells producing these ligands. It cooperates with NKp46 and/or NKp44 in inducing NK-mediated cytotoxicity against the majority of target cells. It is also reported to control NK cells cytotoxicity against tumor cells. Its interaction with BAG6 promotes myeloid dendritic cells (DC) maturation, both through killing DCs that fail to achieve a mature phenotype and by inducing the release of TNF-alpha and interferon-gamma by NK cells that promote DC maturation.NKp30 is synthesized with a signal peptide (aa 1-18), which is subsequently cleaved off to produce the mature protein that contains an extracellular domain (aa 19-135), a transmembrane domain (aa 136-156), and a cytoplasmic domain (aa 157-201). Six isoforms of NKp30 have been described that are produced by alternative splicing.
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Applications
      ApplicationAnti-NKp30, clone 30.95.1, Cat. No. MABF2241, is a mouse monoclonal antibody that detects Natural cytotoxicity triggering receptor 3 (NKp30) and is tested for use in Flow Cytometry.
      Key Applications
      • Flow Cytometry
      Application NotesFlow Cytometry Analysis: A representative lot detected NKp30 in Flow Cytometry applications (Barrow, A.D., et. al. (2018). Cell. 172(3):534-548).

      Note: Actual optimal working dilutions must be determined by end user as specimens, and experimental conditions may vary with the end user
      Biological Information
      ImmunogenHuman NK cells.
      Epitopeextracellular domain
      Clone30.95.1
      Concentration0.5 mg/mL. Please refer to guidance on suggested starting dilutions and/or titers per application and sample type.
      HostMouse
      SpecificityClone 30.95.1 is a mouse monoclonal antibody that detects Natural cytotoxicity triggering receptor 3 (NKp30). It targets an epitope within the extracellular domain.
      IsotypeIgG1κ
      Species Reactivity
      • Human
      Species Reactivity NoteHuman.
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • NCR3
      • IC7
      • LY117
      Purification MethodProtein G purified
      UniProt Number
      Molecular Weight21.59 kDa calculated.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Flow Cytometry in NK-92 cells.

      Flow Cytometry Analysis: 1 µg of this antibody detected NKp30 in one million NK-92 cells.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size25 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      MABF2241-25UL 04061841844488

      Documentation

      Anti-NKp30 Antibody, clone 30.95.1 MSDS

      Title

      Safety Data Sheet (SDS) 

      Anti-NKp30 Antibody, clone 30.95.1 Certificates of Analysis

      TitleLot Number
      Anti-NKp30, clone 30.95.1 - Q3438664 Q3438664

      References

      Reference overviewPub Med ID
      Natural Killer Cells Control Tumor Growth by Sensing a Growth Factor
      Alexander D Barrow 1 , Melissa A Edeling 1 , Vladimir Trifonov 2 , Jingqin Luo 3 , Piyush Goyal 2 , Benjamin Bohl 2 , Jennifer K Bando 1 , Albert H Kim 4 , John Walker 2 , Mary Andahazy 2 , Mattia Bugatti 5 , Laura Melocchi 5 , William Vermi 6 , Daved H Fremont 1 , Sarah Cox 2 , Marina Cella 1 , Christian Schmedt 2 , Marco Colonna
      Cell  172(3)  534-548  2018

      Show Abstract       		29275861 29275861