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ABE1845 Anti-GABPA Antibody

Detect GABPA using this Anti-GABPA Antibody validated for use in Western Blotting and Chromatin Immunoprecipitation (ChIP).

Anti-GABPA Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Epigenetics & Nuclear Function Research Sub-Category: Nuclear Receptors Gene Symbol: Gabpa, E4tf1a UniProt Number: Q00422
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ABE1845
200 μg  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      M, H, RWB, ChIPRbPurifiedPolyclonal Antibody
      Description
      Catalogue NumberABE1845
      DescriptionAnti-GABPA Antibody
      Alternate Names
      • GA-binding protein alpha chain
      • GABP subunit alpha
      • GABPA
      Background InformationGA-binding protein alpha chain (UniProt Q00422; also known as GA repeat binding protein alpha, GABP subunit alpha, GABPalpha, NRF-2, Nuclear respiratory factor-2) is encoded by the Gabpa gene (also known as E4tf1a) in murine species (Gene ID 14390). GABPalpha is a redox-responsive transcription factor that plays an anti-oxidant, pro-survival role in mitochondrial biogenesis process. GABPalpha is upregulated in response to oxidant exposure or increased cellular reactive oxygen species (ROS), where it mediates the transcription of mitochondrial transcription factor A (mtTFA) that is needed for mitochondrial DNA transcription.
      References
      Product Information
      FormatPurified
      PresentationPurified rabbit polyclonal antibody in buffer containing PBS and 0.01% Sodium Azide.
      Quality LevelMQ100
      Applications
      ApplicationDetect GABPA using this Anti-GABPA Antibody validated for use in Western Blotting and Chromatin Immunoprecipitation (ChIP).
      Key Applications
      • Western Blotting
      • Chromatin Immunoprecipitation (ChIP)
      Application NotesWestern Blotting Analysis: A representative lot detected GABPA in mouse liver nuclear proteins (Cherry, A.D., et al. (2014). J. Biol. Chem. 289(1):41-52).
      Chromatin Immunoprecipitation Analysis: A representative lot detected GABPA occupancy at the Sod2 promoter region by ChIP using liver chromatin preparation from mice after S. aureus inoculation (Cherry, A.D., et al. (2014). J. Biol. Chem. 289(1):41-52).
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to mouse GABPA near the C-terminus.
      EpitopeNear C-terminus
      ConcentrationPlease refer to lot specific datasheet.
      HostRabbit
      Species Reactivity
      • Mouse
      • Human
      • Rat
      Species Reactivity NoteMouse, Human, Rat. Predicted to react with Monkey, Bovine, Canine based on 100% sequence homology.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • Gabpa
      • E4tf1a
      Purification MethodProtein A Purfied
      UniProt Number
      Molecular Weight~55 kDa observed
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in mouse liver tissue lysate.

      Western Blotting Analysis: 2.0 µg/mL of this antibody detected GABPA in 10 µg of mouse liver tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size200 μg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      ABE1845 04055977173055

      Documentation

      Anti-GABPA Antibody MSDS

      Title

      Safety Data Sheet (SDS) 

      Anti-GABPA Antibody Certificates of Analysis

      TitleLot Number
      Anti-GABPA - 3290321 3290321
      Anti-GABPA - 3761770 3761770
      Anti-GABPA - 3862584 3862584
      Anti-GABPA - 3933280 3933280
      Anti-GABPA -Q2573216 Q2573216

      Technical Info

      Title
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      White Paper - The Message in the Marks: Deciphering Cancer Epigenetics
      White Paper: Further considerations of antibody validation and usage.